ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2015
Assessing quality of life in Crohn's disease: development and validation of the Crohn's Life Impact Questionnaire (CLIQ).
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic Review of Development and Content Validity of Patient-reported Outcome Measures in Inflammatory Bowel Disease: Do We Measure What We Measure?Journal of Crohn's & colitis · 2020Pooled it
- Inflammatory bowel disease-specific health-related quality of life instruments: a systematic review of measurement properties.Health and quality of life outcomes · 2017Pooled it
- Mirikizumab Sustained Impact on Fatigue in Patients with Moderately to Severely Active Crohn's Disease in the Phase 2 AMAG Study.Inflammatory bowel diseases · 2025Trial
- Understanding data visualization techniques in qualitative studies used to develop and validate patient-reported outcome measures: a targeted literature review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Review
- Identification of spontaneous patient-reported complaints related to perianal fistula in patients with Crohn's disease.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2024Article
- Characteristics and quality of life of people living with comorbid disorders in substance use recovery residences.Frontiers in public health · 2024Article
- Patient-Reported Outcomes in Colorectal Surgery.Clinics in colon and rectal surgery · 2023Review
- What Do We Know about Medication Adherence Interventions in Inflammatory Bowel Disease, Multiple Sclerosis and Rheumatoid Arthritis? A Scoping Review of Randomised Controlled Trials.Patient preference and adherence · 2023Article
- Quality of life and its correlated factors among patients with substance use disorders: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2022Article
- Conceptualisation of a measurement framework for Needs-based Quality of Life among patients with multimorbidity.Journal of patient-reported outcomes · 2022Article
- Role of Quality of Life as Endpoint for Inflammatory Bowel Disease Treatment.International journal of environmental research and public health · 2021Review
- Measuring Quality of Life in Carers of People With Dementia: Development and Psychometric Evaluation of Scales measuring the Impact of DEmentia on CARers (SIDECAR).The Gerontologist · 2021Article
- Fundamental Measurement: The Need Fulfilment Quality of Life (N-QOL) Measure.Innovations in pharmacy · 2021Article
- Fundamental Outcome Measurement: Selecting Patient Reported Outcome Instruments and Interpreting the Data they Produce.Innovations in pharmacy · 2021Article
- The development of the PlexiQoL: A patient-reported outcome measure for adults with neurofibromatosis type 1-associated plexiform neurofibromas.Molecular genetics & genomic medicine · 2020Article
- The National Pharmaceutical Council: Endorsing the Construction of Imaginary Worlds in Health Technology Assessment.Pharmacy (Basel, Switzerland) · 2020Article
- The Great I-QALY Disaster.Innovations in pharmacy · 2020Article
- Development of an Item Pool for a Needs-Based Measure of Quality of Life of Carers of a Family Member with Dementia.The patient · 2019Article
- A qualitative study of the impact of plexiform neurofibromas on need fulfilment in adults with neurofibromatosis type 1.SAGE open medicine · 2019Article
- A Needs-led Framework for Understanding the Impact of Caring for a Family Member With Dementia.The Gerontologist · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeDespite the significant impact of Crohn's disease (CD) on patients' physical and emotional well-being, no CD-specific patient-reported outcome (PRO) measure is available for determining the efficacy of interventions. The objective of the study was to develop and validate the Crohn's Life Impact Scale (CLIQ), the first such measure.
methodsQuestionnaire content was derived from qualitative interviews with CD patients and face and content validity assessed by cognitive debriefing interviews (CDIs) with patients. A postal survey was conducted to identify the final scale, confirm its unidimensionality and determine reproducibility and construct validity. A subset of the respondents was sent a second questionnaire package 2 weeks after the first. The survey included the CLIQ, Nottingham Health Profile (NHP) and Unidimensional Fatigue Impact Scale (U-FIS).
resultsContent analysis was conducted on the 30 interview transcripts and a draft scale produced. The CDIs indicated that the draft scale was relevant, clear and easy to use. The questionnaire package was completed by 273 CD patients (65.6 % male; aged 16-79 (mean 43.9; SD 15.1) years). Of these, 104 also completed the second package. Rasch analysis confirmed a 27-item unidimensional QoL scale (p < 0.05). Both internal consistency and test-retest reliability were high (0.91). Scores on the CLIQ were related to both physical and emotional impairments (NHP) and to fatigue (U-FIS).
conclusionThe CLIQ, the first CD-specific PRO, is unidimensional and has excellent psychometric properties. It should prove to be a valuable tool for evaluating the impact of CD and its treatment from the patients' perspective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.