Evidence map›Paper›PMID 25702263›Full record

ArticleUpdates in surgery2015

Surgery for isolated liver metastases from pancreatic cancer.

Nicola Zanini, Raffaele Lombardi, Michele Masetti, Marco Giordano, Giovanni Landolfo, Elio Jovine

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Updates in surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03398291 (Simultaneous Resection of Pancreatic Cancer and Liver Oligometastasis After Induction Chemotherapy), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03398291 phase3unknown statusnot on this mapstarted 2018, after this paper: background citation

Simultaneous Resection of Pancreatic Cancer and Liver Oligometastasis After Induction Chemotherapy

TypeinterventionalSponsorFudan UniversityRan2018 to 2025Enrolled300ConditionsPancreatic Cancer, Liver Metastases, SurgeryArmsSynchronous resection of primary pancreatic cancer and liver oligometastasis, Standard chemotherapy
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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  17. [Surgery for isolated local recurrence and metachronous oligometastasis in pancreatic cancer].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nicola ZaniniDepartment of Surgery, Maggiore Hospital, Bologna, Italy, nicozanini@gmail.com.
Raffaele Lombardi
Michele Masetti
Marco Giordano
Giovanni Landolfo
Elio Jovine
University of the Republic of San Marino · SM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The resection of liver metastases from pancreatic ductal adenocarcinoma has been discouraged because it is commonly thought that it does not improve survival. However, the role of potential prognostic factors is unclear, and universally accepted strategies have not been proposed. Between 2003 and 2014, 15 patients with isolated synchronous or metachronous metastases from pancreatic cancer underwent liver resection in our department. The role of potential prognostic factors was analyzed to predict survival. One right hepatectomy, 1 bisegmentectomy and 13 wedge resections were performed. Eleven patients underwent simultaneous pancreatic and liver resection for synchronous disease. The median overall survival (OS) was 9.1 months (95% CI 8.6-9.7). The only potential prognostic factor that significatively affected survival was the timing of metastases (metachronous vs. synchronous). Median OS in patients with metachronous disease was 11.4 months (95% CI 0-25.1) vs. 8.3 months (95% CI 6.9-9.7), p = 0.038. Surgery for liver metastases from pancreatic cancer is not suggested for most patients. If resection is considered, timing of metastatic disease could be a prognostic factor for survival after surgery.

Indexed as

AdultAgedBiopsy, Fine-NeedleCarcinoma, Pancreatic DuctalEndosonographyFemaleFollow-Up StudiesHepatectomyHumansLiver NeoplasmsMaleMiddle AgedNeoplasm MetastasisPancreatectomyPancreatic NeoplasmsPrognosis

Identifiers

PMID25702263
OpenAlexW2064813713

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.