ReviewCurrent oncology reports2015
Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors.
Review in Current oncology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Management strategies for pediatric patients with tectal gliomas: a systematic review.Neurosurgical review · 2022Pooled it
- Retrospective comparisons of the dosimetric differences between coplanar and non-coplanar volume-modulated arc therapy in patients with pediatric brainstem glioma.Oncology letters · 2025Article
- Epidemiological characteristics and prognostic factors of high-grade brainstem glioma for all ages and the establishment of a nomogram.Translational cancer research · 2025Article
- Brain stem tumors in children less than 3 months: Clinical and radiologic findings of a rare disease.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Spontaneous Regression of Glioma-Mimicking Brainstem Lesion in a Child: A Case Report.Brain tumor research and treatment · 2024Article
- Clinical, pathological, and radiological features of 80 pediatric diffuse intrinsic pontine gliomas: A single-institute study.Frontiers in oncology · 2023Article
- A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease.Frontiers in oncology · 2023Article
- Brainstem tumors may increase the impairment of behavioral emotional cognition in children.Journal of neuro-oncology · 2022Article
- The Current State of Radiotherapy for Pediatric Brain Tumors: An Overview of Post-Radiotherapy Neurocognitive Decline and Outcomes.Journal of personalized medicine · 2022Review
- Management and outcome of pediatric brainstem and cerebellar peduncular low-grade gliomas: a retrospective analysis of 62 cases.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Current state of therapeutic focused ultrasound applications in neuro-oncology.Journal of neuro-oncology · 2022Review
- Ketogenic diet treatment in diffuse intrinsic pontine glioma in children: Retrospective analysis of feasibility, safety, and survival data.Cancer reports (Hoboken, N.J.) · 2021Article
- Retrospective study of diffuse intrinsic pontine glioma in the Belgian population: a 25 year experience.Journal of neuro-oncology · 2021Article
- Diffuse midline glioma presenting with central sleep apnea and pulmonary hypertension in a 4-year-old patient: a case report.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry.Neuro-oncology · 2020Article
- Surgical treatment and prognosis of focal brainstem gliomas in children: A 7 year single center experience.Medicine · 2020Article
- Diverse immunotherapies can effectively treat syngeneic brainstem tumors in the absence of overt toxicity.Journal for immunotherapy of cancer · 2019Article
- Passive Immunotherapies for Central Nervous System Disorders: Current Delivery Challenges and New Approaches.Bioconjugate chemistry · 2018Review
- Unexpected death of a 9-year-old girl.Brain pathology (Zurich, Switzerland) · 2018Article
- Diffuse intrinsic pontine gliomas (DIPG) at recurrence: is there a window to test new therapies in some patients?Journal of neuro-oncology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pediatric brainstem gliomas include low-grade focal brainstem gliomas (FBSG) and high-grade diffuse intrinsic pontine gliomas (DIPG). These tumors share a crucial and eloquent area of the brain as their location, which carries common challenges for treatment. Otherwise, though, these two diseases are very different in terms of presentation, biology, treatment, and prognosis. FBSG usually present with greater than 3 months of symptoms, while DIPG are usually diagnosed within 3 months of symptom onset. Surgery remains the preferred initial treatment for FBSG, with chemotherapy used for persistent, recurrent, or inoperable disease; conversely, radiation is the only known effective treatment for DIPG. Recent developments in biological understanding of both tumors have led to new treatment possibilities. In FBSG, two genetic changes related to BRAF characterize the majority of tumors, and key differences in their biological effects are informing strategies for targeted chemotherapy use. In DIPG, widespread histone H3 and ACVR1 mutations have led to new hope for effective targeted treatments. FBSG has an excellent prognosis, while the long-term survival rate of DIPG tragically remains near zero. In this review, we cover the epidemiology, biology, presentation, imaging characteristics, multimodality treatment, and prognosis of FBSG and DIPG, with a focus on recent biological discoveries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.