Evidence map›Paper›PMID 25701691›Full record

Observational studyJournal of pain and symptom management2015

Fatigue in HIV-Infected People: A Three-Year Observational Study.

Julie Barroso, Jane Leserman, James L Harmon, Bradley Hammill, Brian W Pence

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Journal of pain and symptom management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Julie BarrosoSchool of Nursing and Health Studies, University of Miami, Coral Gables, Florida, USA. Electronic address: j.barroso1@miami.edu.
Jane LesermanDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
James L HarmonDuke University School of Nursing, Durham, North Carolina, USA.
Bradley HammillDuke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Brian W PenceGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Duke University · USUniversity of North Carolina at Chapel Hill · USUniversity of Miami · US

Funding

Pilot Project for the DTMI CRA ProgramUL1RR024128 · NCRR · DUKE UNIVERSITY · PI CALIFF, ROBERT M · 2006 to 2010
$48.1M
XOMAZYME-CD5 PLUS THERAPY IN RHEUMATOID ARTHRITISM01RR000030 · NCRR · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 1985 to 2006
$20.0M
Fatigue in HIV-Positive PeopleR01NR008681 · NINR · DUKE UNIVERSITY · PI BARROSO, JULIE V · 2004 to 2008
$2.5M
NCRR NIH HHS 1UL1RR024128-01NCRR NIH HHS M01 RR000030NCRR NIH HHS UL1 RR024128NINR NIH HHS 5R01NR008681NINR NIH HHS R01 NR008681
6 · The paper itself

Abstract

contextHIV-related fatigue remains the most frequent complaint of seropositive patients.

objectivesTo describe the natural course of fatigue in HIV infection, in a sample (n=128) followed for a three-year period.

methodsA longitudinal prospective design was used to determine what factors influenced changes in fatigue intensity and fatigue-related impairment of functioning in a community-dwelling sample of HIV-infected individuals. Participants were followed every six months for a three-year period. At each study visit, we collected data on a large number of physiological and psychosocial markers that have been shown to be related to fatigue in HIV-infected people. At three month intervals between study visits, we collected data on fatigue via mailed questionnaires.

resultsFatigue in HIV infection is largely a result of stressful life events, and is closely tied to the anxiety and depression that accompany such events. Fatigue did not remit spontaneously over the course of the study, indicating the need for interventions to ameliorate this debilitating symptom.

conclusionIntervening to help people who are suffering from HIV-related fatigue to deal with stressful life events may help to ameliorate this debilitating symptom.

Indexed as

AdultAgedAnxietyDisease ProgressionFatigueFemaleHIV InfectionsHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesStress, PsychologicalTime FactorsfatigueHIVphysiological factorspsychosocial factors

Identifiers

PMID25701691
PMCPMC4492863
OpenAlexW2023008856

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.