ArticleUltrasound in medicine & biology2015
Free-hand ultrasound guidance permits safe and efficient minimally invasive intrathymic injections in both young and aged mice.
Article in Ultrasound in medicine & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Cre-dependent gene expression enables thymic development of autoreactive tumor-associated antigen targeting CAR-T cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- A Minimally Invasive, Accurate, and Efficient Technique for Intrathymic Injection in Mice.Journal of visualized experiments : JoVE · 2022Article
- Ultrasound Monitoring of Thymus Involution in Septic Mice.Ultrasound in medicine & biology · 2021Article
- Intrathymic injection of hematopoietic progenitor cells establishes functional T cell development in a mouse model of severe combined immunodeficiency.Journal of hematology & oncology · 2017Article
- Murine ultrasound-guided transabdominal para-aortic injections of self-assembling type I collagen oligomers.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Treatment of surgical brain injury by immune tolerance induced by intrathymic and hepatic portal vein injection of brain antigens.Scientific reports · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The goal of this study was to evaluate whether use of an aseptic free-hand approach to ultrasound-guided injection facilitates injection into the thymic gland in mice. We used this interventional radiology technique in young, aged and immunodeficient mice and found that the thymus was visible in all cases. The mean injection period was 8 seconds in young mice and 19 seconds in aged or immunodeficient mice. Injection accuracy was confirmed by intrathymic location of an injected dye or by in vivo bioluminescence imaging of injected luciferase-expressing cells. Accurate intrathymic injection was confirmed in 97% of cases. No major complications were observed. We conclude that an aseptic freehand technique for ultrasound-guided intrathymic injection is safe and accurate and reduces the time required for intrathymic injections. This method facilitates large-scale experiments and injection of individual thymic lobes and is clinically relevant.
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Registered trials
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