ArticleMolecular biology and evolution2015
Gene-wide identification of episodic selection.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 419 papers.
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Who cites it
419 citing papers in PubMed.
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- Evolutionary Shifts in Rhodopsin Function Illuminate Dim-Light Adaptations in Birds.Integrative zoology · 2026Article
- Widespread horizontal transfer and strong selection enhance microbial adaptation in Antarctic soils.Nature communications · 2026Article
- Complete Mitochondrial Genome of Turrum coeruleopinnatum Provides Phylogenetic Context and Candidate Selection Signals Within Carangidae.Biochemical genetics · 2026Article
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- Frozen and Scorched: Genomic Signatures of Adaptive Divergence and Hibernation in the Living FossilEcology and evolution · 2026Article
- CAPHEINE, or Everything and the Kitchen Sink: A Workflow for Automating Selection Analyses Using HyPhy.Genome biology and evolution · 2026Article
- First mitochondrial genomes in the Effusa clade (Gastropoda, Ampullariidae): unveiling new insights from Neotropical endemic Pomacea spp.BMC genomics · 2026Article
- Epistasis facilitates the long-term antigenic evolution of the influenza B virus hemagglutinin.bioRxiv : the preprint server for biology · 2026Article
- DNA transposon expansion drives genome plasticity in Diutina catenulata.Nature communications · 2026Article
- The genetic foundations of convergent traits.Nature reviews. Genetics · 2026Review
- Evolutionary History of the α-Carbonic Anhydrase Gene Family in the Phylum Arthropoda, With Comparisons to αCA in Chordates.Genome biology and evolution · 2026Article
359 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
Abstract
We present BUSTED, a new approach to identifying gene-wide evidence of episodic positive selection, where the non-synonymous substitution rate is transiently greater than the synonymous rate. BUSTED can be used either on an entire phylogeny (without requiring an a priori hypothesis regarding which branches are under positive selection) or on a pre-specified subset of foreground lineages (if a suitable a priori hypothesis is available). Selection is modeled as varying stochastically over branches and sites, and we propose a computationally inexpensive evidence metric for identifying sites subject to episodic positive selection on any foreground branches. We compare BUSTED with existing models on simulated and empirical data. An implementation is available on www.datamonkey.org/busted, with a widget allowing the interactive specification of foreground branches.
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