Evidence map›Paper›PMID 25701094›Full record

ReviewTrends in cardiovascular medicine2015

Ionic mechanisms of arrhythmogenesis.

Justus M Anumonwo, Sandeep V Pandit

Abstract readReview
In one paragraph

Review in Trends in cardiovascular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Sodium channel biophysics, late sodium current and genetic arrhythmic syndromes.Pflugers Archiv : European journal of physiology · 2017
    Review
  8. Article
  9. Article
  10. Mechanisms of cardiac arrhythmias.Journal of arrhythmia · 2016
    Review
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Justus M AnumonwoDepartment of Internal Medicine-Cardiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI. Electronic address: anumonwo@med.umich.edu.
Sandeep V PanditDepartment of Internal Medicine-Cardiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI.
University of Michigan–Ann Arbor · US

Funding

Intermolecular Interactions of NaV1.5 and Kir2.1 In Ion Channel DiseasesR01HL122352 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERENFELD, OMER · 2015 to 2018
$1.9M
Mapping Electrical Activation in Atrial FibrillationR01HL118304 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERENFELD, OMER · 2013 to 2016
$1.5M
Arrhythmogenicity of human SAP97 Mutations in patient specific iPSC-CMs and MiceR01HL124319 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANUMONWO, JUSTUS M · 2015 to 2017
$1.3M
Arrhythmogenicity of human SAP97 Mutations in patient specific iPSC-CMs and MiceR56HL124319 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANUMONWO, JUSTUS M · 2014 to 2014
$485k
NHLBI NIH HHS 1R56HL124319-01NHLBI NIH HHS HL118304NHLBI NIH HHS HL122352NHLBI NIH HHS R01 HL118304NHLBI NIH HHS R01 HL122352NHLBI NIH HHS R01 HL124319NHLBI NIH HHS R56 HL124319
6 · The paper itself

Abstract

The understanding of ionic mechanisms underlying cardiac rhythm disturbances (arrhythmias) is an issue of significance in the medical science community. Several advances in molecular, cellular, and optical techniques in the past few decades have substantially increased our knowledge of ionic mechanisms that are thought to underlie arrhythmias. The application of these techniques in the study of ion channel biophysics and regulatory properties has provided a wealth of information, with some important therapeutic implications for dealing with the disease. In this review, we briefly consider the cellular and tissue manifestations of a number of cardiac rhythm disturbances, while focusing on our current understanding of the ionic current mechanisms that have been implicated in such rhythm disturbances.

Indexed as

Cardiac ElectrophysiologyArrhythmias, CardiacAutomationCalcium ChannelsElectrocardiographyFemaleHumansIon ChannelsMaleSensitivity and SpecificitySodium ChannelsCalcium ChannelsIon ChannelsSodium Channels

Identifiers

PMID25701094
PMCPMC4504834
OpenAlexW2051347864

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.