ArticleNeuroImage2015
Quantitative tract-based white matter heritability in twin neonates.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01409746 (Early Brain Development in Twins), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Brain Development in Twins
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.Biological psychiatry · 2023Pooled it
- Genetic and environmental influence on white matter: insight from an Italian twin population study.Frontiers in human neuroscience · 2026Article
- Tractometry of the Human Connectome Project: resources and insights.Frontiers in neuroscience · 2024Article
- An augmented Mendelian randomization approach provides causality of brain imaging features on complex traits in a single biobank-scale dataset.PLoS genetics · 2023Article
- The adaptive stochasticity hypothesis: Modeling equifinality, multifinality, and adaptation to adversity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- White matter microstructure predicts individual differences in infant fear (But not anger and sadness).Developmental science · 2023Article
- Patterns of risk-Using machine learning and structural neuroimaging to identify pedophilic offenders.Frontiers in psychiatry · 2023Article
- The developing brain structural and functional connectome fingerprint.Developmental cognitive neuroscience · 2022Article
- Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes.Biostatistics (Oxford, England) · 2022Article
- Heritable anisotropy associated with cognitive impairments among patients with schizophrenia and their non-psychotic relatives in multiplex families.Psychological medicine · 2022Article
- Existence of Functional Connectome Fingerprint during Infancy and Its Stability over Months.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Diffusion Tensor Based White Matter Tract Atlases for Pediatric Populations.Frontiers in neuroscience · 2022Article
- Genetic and environmental influences of variation in diffusion MRI measures of white matter microstructure.Brain structure & function · 2022Article
- Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n = 17,706).Molecular psychiatry · 2021Article
- Genome-Wide Association Analysis of Neonatal White Matter Microstructure.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- White Matter Development from Birth to 6 Years of Age: A Longitudinal Study.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- The role of the fornix in human navigational learning.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Article
- Development and Emergence of Individual Variability in the Functional Connectivity Architecture of the Preterm Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- White matter development in infants at risk for schizophrenia.Schizophrenia research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Studies in adults indicate that white matter microstructure, assessed with diffusion tensor imaging (DTI), has high heritability. Little is known about genetic and environmental influences on DTI parameters, measured along fiber tracts particularly, in early childhood. In the present study, we report comprehensive heritability data of white matter microstructure fractional anisotropy (FA), radial diffusion (RD), and axial diffusion (AD) along 47 fiber tracts using the quantitative tractography in a large sample of neonatal twins (n=356). We found significant genetic influences in almost all tracts with similar heritabilities for FA, RD, and AD as well as positive relationships between these parameters and heritability. In a single tract analysis, genetic influences along the length of the tract were highly variable. These findings suggest that at birth, there is marked heterogeneity of genetic influences of white matter microstructure within white matter tracts. This study provides a basis for future studies of developmental changes in genetic and environmental influences during early childhood, a period of rapid development that likely plays a major role in individual differences in white matter structure and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.