ArticleJournal of oral microbiology2015
Polymorphisms in the interleukin-10 gene and chronic periodontitis in patients with atherosclerotic and aortic aneurysmal vascular diseases.
Article in Journal of oral microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis.Medicine · 2019Pooled it
- The Association of Periodontitis and Peripheral Arterial Occlusive Disease-A Systematic Review.International journal of molecular sciences · 2019Pooled it
- The role of three interleukin 10 gene polymorphisms (- 1082 A > G, - 819 C > T, - 592 A > C) in the risk of chronic and aggressive periodontitis: a meta-analysis and trial sequential analysis.BMC oral health · 2018Pooled it
- Relationship between Periodontitis and Rheumatoid Arthritis: Review of the Literature.Mediators of inflammation · 2015Review
- Polymerase chain reaction: A molecular diagnostic tool in periodontology.Journal of Indian Society of PeriodontologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic periodontitis (CP), atherosclerotic and aortic aneurysmal vascular diseases (VD) are chronic inflammatory conditions with multifactorial etiologies, including involvement of predisposing genetic factors. In a previous study, polymorphisms in the gene for the anti-inflammatory interleukin-1 receptor antagonist were associated with CP in patients with VD.
objectiveThis study investigates whether polymorphisms in the gene for the anti-inflammatory interleukin-10 (IL10) could be related to CP in the same manner.
methodsSeventy-two patients with VD of whom 35 had CP were genotyped for single nucleotide polymorphisms (SNPs) in the IL10 -592 (rs1800872), -819 (rs1800871), and -1,082 (rs1800896) gene by Taqman rtPCR method and by DNA sequencing.
resultsThe C alleles and C/C genotypes of IL10 -592 and IL10 -819 frequencies were significantly higher, while the frequencies of the IL10 -592 (C/A) and IL10 -819 (C/T) heterozygote genotypes were significantly lower in the VD group with CP compared to those without CP. The IL10 haplotype ATA frequency (-1,082, -819, -592) showed a trend to a significant difference between the two groups indicating protection against CP.
conclusionsTaken together, our findings suggest an independent association of genetic polymorphisms in the IL-10 gene locus with CP in patients with VD. Development of CP and the implications on vascular disease emphasize the importance of early detection and adequate treatment of periodontitis among these patients.
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