Trial reportThe European respiratory journal2015
Effects of antenatal multiple micronutrient supplementation on lung function in mid-childhood: follow-up of a double-blind randomised controlled trial in Nepal.
Trial report in The European respiratory journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019Pooled it
- Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis.PLoS medicine · 2018Pooled it
- Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2017Pooled it
- Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and meta-analysis.BMC medicine · 2016Pooled it
- Vitamin supplementation for preventing miscarriage.The Cochrane database of systematic reviews · 2016Pooled it
- Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2015Pooled it
- Article
- Preterm birth, birth weight, infant weight gain and their associations with childhood asthma and spirometry: a cross-sectional observational study in Nairobi, Kenya.BMJ open respiratory research · 2023Observational
- Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis.ERJ open research · 2023Review
- Dietary Factors May Delay Tolerance Acquisition in Food Protein-Induced Allergic Proctocolitis.Nutrients · 2023Observational
- Food Protein-Induced Allergic Proctocolitis: The Effect of Maternal Diet During Pregnancy and Breastfeeding in a Mediterranean Population.Frontiers in nutrition · 2022Article
- Breathing-Focused Yoga Intervention on Respiratory Decline in Chronically Pesticide-Exposed Farmers: A Randomized Controlled Trial.Frontiers in medicine · 2022Article
- Effects of vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries: A systematic review.Campbell systematic reviews · 2021Article
- Birth weight and prematurity with lung function at ~17.5 years: "Children of 1997" birth cohort.Scientific reports · 2020Article
- Article
- ERS/ATS workshop report on respiratory health effects of household air pollution.The European respiratory journal · 2018Article
- Long-term effects of severe acute malnutrition on lung function in Malawian children: a cohort study.The European respiratory journal · 2017Article
- Chronic respiratory disease - the acceptable epidemic?Clinical medicine (London, England) · 2017Review
- Explaining ethnic disparities in lung function among young adults: A pilot investigation.PloS one · 2017Article
- Cross-sectional study of asthma and rhinitis symptoms in the context of exposure to air pollution in Nepal.ERJ open research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
A randomised trial of prenatal multiple micronutrient supplementation in Nepalese women increased birthweight and weight at 2 years of age in offspring, compared to those born to mothers who only received iron and folic acid supplements. Further follow-up of this cohort provided an opportunity to investigate the effect of antenatal multiple micronutrients on subsequent lung function by measuring spirometry at 7-9 years of age in C: hildren born during the trial. 841 children (80% of the cohort) were seen at mean±sd 8.5±0.4 years. Technically successful spirometry results were obtained in 793 (94.3%) children, 50% of whom had been randomised to micronutrient supplementation. Background characteristics, including anthropometry, were similar in the two allocation groups. Lung function was also similar, mean (95% CI) difference in z-scores (supplementation minus control) was -0.08 (-0.19-0.04), -0.05 (-0.17-0.06) and -0.04 (-0.15-0.07) for forced expiratory volume in 1 s (FEV1), forced vital capacity and FEV1/FVC, respectively. Compared with healthy white children, FEV1 and FVC in the "healthy" Nepalese children were ∼1 (∼13%) z-score lower, with no difference in FEV1/FVC. We conclude that, compared with routine iron and folic acid, multiple micronutrient supplementation during pregnancy has no effect on spirometric lung function in Nepalese children at 8.5 years of age.
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