ArticleThe European respiratory journal2015
African ancestry, lung function and the effect of genetics.
Article in The European respiratory journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- The chronological age at which small airway function starts to decline in a healthy Chinese population: a cross-sectional study.Frontiers in allergy · 2025Article
- Association of Preoperative Lung Function with Complications after Lobectomy Using Race-Neutral and Race-Specific Normative Equations.Annals of the American Thoracic Society · 2024Article
- How to account for Inuit ancestry in lung function prediction.International journal of circumpolar health · 2023Article
- Impact of Spirometry Race-Correction on Preadolescent Black and White Children.The journal of allergy and clinical immunology. In practice · 2023Article
- Reference equations for evaluation of spirometry function tests in South Asia, and among South Asians living in other countries.The European respiratory journal · 2022Article
- Article
- COVID-19: Unique public health issues facing Black, Asian and minority ethnic communities.Current problems in cardiology · 2020Review
- Validation of the global lung initiative 2012 multi-ethnic spirometric reference equations in healthy urban Zimbabwean 7-13 year-old school children: a cross-sectional observational study.BMC pulmonary medicine · 2020Observational
- African ancestry is associated with cluster-based childhood asthma subphenotypes.BMC medical genomics · 2018Article
- Evaluating genetic ancestry and self-reported ethnicity in the context of carrier screening.BMC genetics · 2017Article
- Bringing Lung Function Prediction Equations to Diverse Populations.American journal of respiratory and critical care medicine · 2017Article
- What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression.Current allergy and asthma reports · 2016Review
- Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies.American journal of respiratory and critical care medicine · 2016Article
- Challenges in Collating Spirometry Reference Data for South-Asian Children: An Observational Study.PloS one · 2016Observational
- Lung function in children in relation to ethnicity, physique and socioeconomic factors.The European respiratory journal · 2015Article
- Mapping asthma-associated variants in admixed populations.Frontiers in genetics · 2015Review
- Race, ethnicity and lung function: A brief history.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2015Article
- Spirometry reference values for Black adults in Brazil.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaArticle
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
African-Americans have smaller lung function compared with European-Americans. The aim of this study was to disentangle the contribution of genetics from other variables on lung function. A cohort was followed from birth to 30 years of age in Brazil. Several variables were collected: genomic analysis based on DNA; forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) obtained by spirometry; height measured by anthropometrists; and thorax circumference evaluated by photonic scanner. Crude and adjusted linear regression models were calculated according to African ancestry. The sample comprised 2869 participants out of 3701 members of the cohort. Males with higher African ancestry by DNA analysis had a smaller FEV1 (-0.13 L, 95% CI -0.23- -0.03 L) and FVC (-0.21 L, 95% CI -0.32- -0.09 L) compared with those with less African ancestry, having accounted for height, sitting to standing height ratio and other confounders. Similar effects were seen in females. After adjustment, ancestry remained significantly associated with lung function, but the large effect of adjustment for confounding among males (but not females) does not allow us to exclude the possibility that residual confounding may still account for these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.