Evidence map›Paper›PMID 25700226›Full record

ArticleJournal of computer assisted tomography

Repeatability Investigation of Reduced Field-of-View Diffusion-Weighted Magnetic Resonance Imaging on Thyroid Glands.

Yonggang Lu, Vaios Hatzoglou, Suchandrima Banerjee, Hilda E Stambuk, Mithat Gonen, Ajit Shankaranarayanan, Yousef Mazaheri, Joseph O Deasy, Ashok R Shaha, R Michael Tuttle and 1 more

Open access · hybridAbstract readEvaluation Study
In one paragraph

Article in Journal of computer assisted tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

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  11. Gallbladder carcinoma: an initial clinical experience of reduced field-of-view diffusion-weighted MRI.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yonggang LuFrom the Departments of *Medical Physics and †Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY; ‡Global Applied Sciences Laboratory, GE Healthcare, Menlo Park, CA; and Departments of §Epidemiology and Biostatistics, ∥Surgery, and ¶Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY.
Vaios Hatzoglou
Suchandrima Banerjee
Hilda E Stambuk
Mithat Gonen
Ajit Shankaranarayanan
Yousef Mazaheri
Joseph O Deasy
Ashok R Shaha
R Michael Tuttle
Amita Shukla-Dave
Applied Sciences Laboratory (United States) · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
SPORE in Thyroid CancerP50CA172012 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI FAGIN, JAMES A · 2014 to 2018
$10.3M
Predictive MRI metrics for tumor aggressiveness in micropapillary thyroid cancerR21CA176660 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DAVE, AMITA · 2014 to 2015
$737k
NCI NIH HHS 1R21CA176660-01A1NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA172012NCI NIH HHS R21 CA176660
6 · The paper itself

Abstract

objectiveTo investigate the repeatability of the quantitative magnetic resonance imaging (MRI) metric (apparent diffusion coefficient [ADC]) derived from reduced field-of-view diffusion-weighted (rFOV DWI) on thyroid glands in a clinical setting. MATERIALS AND

methodsTen healthy human volunteers were enrolled in MRI studies performed on a 3-T MRI scanner. Each volunteer was designed to undergo 3 longitudinal examinations (2 weeks apart) with 2 repetitive sessions within each examination, which included rFOV and conventional full field-of-view (fFOV) DWI scans. Diffusion-weighted images were assessed and scored based on image characteristics. Apparent diffusion coefficient values of thyroid glands from all participants were calculated based on regions of interest. Repeatability analysis was performed based on the framework proposed by the Quantitative Imaging Biomarker Alliance, generating 4 repeatability metrics: within-participant variance ((Equation is included in full-text article.)), repeatability coefficients, intraclass correlation coefficient, and within-participant coefficient of variation. Student t test was used to compare the performance difference between rFOV and fFOV DWI.

resultsThe overall image quality from rFOV DWI was significantly higher than that from fFOV DWI (P = 0.04). The ADC values calculated from rFOV DWI were significantly lower than corresponding values from fFOV DWI (P < 0.001). There was no significant difference in ADC values across sessions and examinations in either rFOV or fFOV DWI (P > 0.05). Reduced field-of-view DWI had lower values of (Equation is included in full-text article.), repeatability coefficient, and within-participant coefficient of variation and had a higher value of intraclass correlation coefficient compared with fFOV DWI across either sessions or examinations.

conclusionsThis study demonstrated that rFOV DWI produced more superior-quality DWI images and more repeatable ADC measurements compared with fFOV DWI, thus providing a feasible quantitative imaging tool for investigating thyroid glands in clinical settings.

Indexed as

AlgorithmsAdultDiffusion Magnetic Resonance ImagingHumansImage EnhancementImage Interpretation, Computer-AssistedMiddle AgedReference ValuesReproducibility of ResultsSensitivity and SpecificityThyroid GlandYoung Adult

Identifiers

PMID25700226
PMCPMC4433417
OpenAlexW2331243214

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.