Evidence map›Paper›PMID 25699996›Full record

SynthesisJournal of the American Heart Association2015

Prehypertension and the risk of coronary heart disease in Asian and Western populations: a meta-analysis.

Yuli Huang, Xiaoyan Cai, Changhua Liu, Dingji Zhu, Jinghai Hua, Yunzhao Hu, Jian Peng, Dingli Xu

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  5. Hypertension in a Randomized Trial of Dolutegravir- Versus Efavirenz-Based Antiretroviral Therapy in Pregnant and Postpartum Women with HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuli HuangDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Y.H., C.L., D.Z., J.H., J.P., D.X.).
Xiaoyan CaiDepartment of Cardiology, the First People's Hospital of Shunde, Foshan, China (X.C., Y.H.).
Changhua LiuDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Y.H., C.L., D.Z., J.H., J.P., D.X.).
Dingji ZhuDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Y.H., C.L., D.Z., J.H., J.P., D.X.).
Jinghai HuaDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Y.H., C.L., D.Z., J.H., J.P., D.X.).
Yunzhao HuDepartment of Cardiology, the First People's Hospital of Shunde, Foshan, China (X.C., Y.H.).
Jian PengDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Y.H., C.L., D.Z., J.H., J.P., D.X.).
Dingli XuDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Y.H., C.L., D.Z., J.H., J.P., D.X.).
Nanfang Hospital · CNThe First People's Hospital of Shunde · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe results of studies on the association between prehypertension (blood pressure 120 to 139/80 to 89 mm Hg) and coronary heart disease (CHD) remain controversial. Furthermore, it is unclear whether prehypertension affects the risk of CHD in Asian and Western populations differently. This meta-analysis evaluated the risk of CHD associated with prehypertension and its different subgroups. METHODS AND

resultsThe PubMed and Embase databases were searched for prospective cohort studies with data on prehypertension and the risk of CHD. Studies were included if they reported multivariate-adjusted relative risks (RRs) with 95% CIs of CHD from prehypertension. A total of 591 664 participants from 17 prospective cohort studies were included. Prehypertension increased the risk of CHD (RR 1.43, 95% CI 1.26 to 1.63, P<0.001) compared with optimal blood pressure (<120/80 mm Hg). The risk of CHD was higher in Western than in Asian participants (Western: RR 1.70, 95% CI 1.49 to 1.94; Asian: RR 1.25, 95% CI 1.12 to 1.38; ratio of RRs 1.36, 95% CI 1.15 to 1.61). The population-attributable risk indicated that 8.4% of CHD in Asian participants was attributed to prehypertension, whereas this proportion was 24.1% in Western participants.

conclusionsPrehypertension, even at the low range, is associated with an increased risk of CHD. This risk is more pronounced in Western than in Asian populations. These results supported the heterogeneity of target-organ damage caused by prehypertension and hypertension among different ethnicities and underscore the importance of prevention of CHD in Western patients with prehypertension.

Indexed as

Blood PressureAsian PeopleCoronary DiseaseHumansIncidencePrehypertensionRiskRisk AssessmentRisk FactorsWhite Peoplecardiovascular diseasecoronary heart diseaseprehypertensionrisk

Identifiers

PMID25699996
PMCPMC4345875
OpenAlexW2132340136

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.