Evidence map›Paper›PMID 25699982›Full record

ReviewCardiology in review

Circulating Biomarkers Predictive of Postoperative Atrial Fibrillation.

Mohit K Turagam, Mahek Mirza, Paul H Werner, Jasbir Sra, David C Kress, A Jamil Tajik, Arshad Jahangir

Abstract readReview
In one paragraph

Review in Cardiology in review. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  15. Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease.Journal of cardiovascular development and disease · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohit K TuragamFrom the *Sheikh Khalifa bin Hamad Al Thani Center for Integrative Research on Cardiovascular Aging (CIRCA), Aurora University of Wisconsin Medical Group, Aurora Research Institute, Aurora Health Care, Milwaukee, WI; †University of Missouri-Columbia School of Medicine, Columbia, MO; ‡Aurora Medical Group - Cardiovascular and Thoracic Surgery, Aurora St. Luke's Medical Center, Milwaukee, WI; and §Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, Milwaukee, WI.
Mahek Mirza
Paul H Werner
Jasbir Sra
David C Kress
A Jamil Tajik
Arshad Jahangir

Funding

Mitochondrial Dysfunction and Susceptibility to Atrial Fibrillation in the ElderlR01HL101240 · NHLBI · MAYO CLINIC ARIZONA · PI JAHANGIR, ARSHAD · 2010 to 2013
$2.3M
Human Senescence and CardioprotectionR01HL089542 · NHLBI · MAYO CLINIC ROCHESTER · PI JAHANGIR, ARSHAD · 2008 to 2011
$1.6M
NHLBI NIH HHS R01 HL089542NHLBI NIH HHS R01 HL101240
6 · The paper itself

Abstract

Postoperative atrial fibrillation (PoAF), a common complication of cardiac surgery, contributes significantly to morbidity, mortality, and increasing healthcare costs. Despite advances in surgical and medical management, the overall incidence of PoAF has not changed significantly, partly because of the limited understanding of mechanisms underlying acute surgery-related factors, such as myocardial injury, inflammation, sympathetic activation, and oxidative stress, which play an important role in the initiation of PoAF, whereas a preexisting atrial substrate appears to be more important in the maintenance of this dysrhythmia. Thus, in a majority of patients, PoAF becomes a manifestation of an underlying arrhythmogenic substrate that is unmasked after acute surgical stress. As such, the ability to identify which patients have this proarrhythmic substrate and are, therefore, at high risk for developing AF postoperatively, is important for the improved selection for prophylactic interventions, closer monitoring for complications, and establishing the probability of AF in the long term. This review highlights the role of the underlying substrate in promoting PoAF, proposed mechanisms, and the potential role of serum biomarkers to identify patients at risk for PoAF.

Indexed as

Postoperative ComplicationsAtrial FibrillationBiomarkersCardiac Surgical ProceduresHumansPrognosisBiomarkers

Identifiers

PMID25699982
PMCPMC4944526

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.