ArticleClinical sarcoma research2015
Primary Synovial Sarcoma (SS) of the digestive system: a molecular and clinicopathological study of fifteen cases.
Article in Clinical sarcoma research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Synovial sarcoma of the stomach: a case report and a systematic review of literature.Clinical journal of gastroenterology · 2021Pooled it
- Diffuse, Aggressive Metastatic Progression after Minimally Invasive Local Resection of Primary Gastric Synovial Sarcoma: a Case Report and Systematic Review of the Literature.Journal of gastrointestinal cancer · 2019Pooled it
- Laparoscopic-endoscopic cooperative surgery for primary gastric synovial sarcoma: a rare case report and literature review.Frontiers in oncology · 2026Article
- Biphasic synovial sarcoma with myoepithelial features: a distinctive variant with a predilection for the foot.Virchows Archiv : an international journal of pathology · 2024Article
- Non-gastrointestinal stromal tumor, mesenchymal neoplasms of the gastrointestinal tract: a review of tumor genetics, pathology, and cross-sectional imaging findings.Abdominal radiology (New York) · 2024Review
- Synovial sarcoma of the viscera (lung and jejunum): a case report.The Journal of international medical research · 2024Article
- Small gastric synovial sarcoma diagnosed and treatment by laparoscopic-endoscopic cooperative surgery: a case report.Clinical journal of gastroenterology · 2024Article
- A case of primary mesenteric synovial sarcoma: a challenging presentation.Surgical case reports · 2023Article
- Primary Gastric Synovial Sarcoma in a Young Male: a Rare Case Report and Review of Literature.Indian journal of surgical oncology · 2023Article
- Clinicopathologic features of a patient with primary monophasic synovial sarcoma of the jejunum.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Article
- Article
- Case Report: Submucosal gastroblastoma with a novelFrontiers in oncology · 2022Article
- A minute primary gastric synovial sarcoma with ulcer: a case report.Diagnostic pathology · 2021Article
- Primary gastric synovial sarcoma resected by laparoscopic endoscopic cooperative surgery of the stomach: a case report.Surgical case reports · 2021Article
- Mesenchymal tumours of the gastrointestinal tract.Pathologica · 2021Review
- Clear cell sarcoma-like/malignant gastrointestinal neuroectodermal tumor of the tongue: a clinicopathologic and molecular case report.Virchows Archiv : an international journal of pathology · 2021Article
- Primary rectal monophasic synovial sarcoma.Proceedings (Baylor University. Medical Center) · 2021Article
- Laparoscopic intragastric resection of gastric synovial sarcoma: report of the first ever case with video demonstration.World journal of surgical oncology · 2021Article
- Primary malignant ossifying fibromyxoid tumour of the bone. A clinicopathologic and molecular report of two cases.Pathologica · 2020Article
- American Registry of Pathology Expert Opinions: Evaluation of poorly differentiated malignant neoplasms on limited samples - Gastrointestinal mucosal biopsies.Annals of diagnostic pathology · 2020Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently a few cases of synovial sarcoma (SS) of the abdominal viscera have been reported, raising awareness about the potential for confusion between this entity and KIT-negative gastrointestinal stromal tumors (GIST). We report the clinicopathological, immunophenotypical and molecular features of fifteen more SS occurring in the stomach (8 cases), epigastric region (one case), small intestine (one case), large intestine (three cases), involving both the terminal ileum and the caecum (one case) and liver (one case).
methodsImmunostains for SMA, DESMIN, CD34, CD117, S100, EMA, CK AE1/3, TLE1, CD56, CD99, BCL2, DOG1 were performed. Rearrangement of SS18 gene region was screened in all cases: by conventional karyotype in one case, the remaining cases were screened either by interphase FISH or Q-PCR or both.
resultsTen patients were male and five female, with an age range of 17-61 years (median 44). Tumor size ranged from 2 to 15 cm (median 8). Mitoses per 10 HPF ranged from 4 to 27 (median 9.5). Eleven tumors were monophasic fibrous SS, one biphasic SS and three poorly differentiated SS. SMA, Desmin, CD34, CD117 and S100 were negative in all cases, whereas EMA and/or CK AE1/AE3 were positive in all cases. TLE1, BCL2 and CD56 were positive in all tested cases. DOG1 was positive in one case. SS18 gene region rearrangement was demonstrated in all cases. A fusion transcript was amplified in eight cases: either SS18-SSX2 or SS18-SSX1 respectively in four cases each.
conclusionsSS is increasingly recognized at visceral sites. Molecular analyses play a key role when dealing with usual histotypes in unusual sites. Correct diagnosis is crucial for appropriate therapy.
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