Evidence map›Paper›PMID 25698909›Full record

ArticleSIAM journal on applied dynamical systems

Calcium and Metabolic Oscillations in Pancreatic Islets: Who's Driving the Bus?

Margaret Watts, Bernard Fendler, Matthew J Merrins, Leslie S Satin, Richard Bertram, Arthur Sherman

Abstract read
In one paragraph

Article in SIAM journal on applied dynamical systems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Mathematical Modelling of Endocrine Systems.Trends in endocrinology and metabolism: TEM · 2019
    Review
  7. Review
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Margaret WattsNational Institutes of Health, Bethesda, MD 20892. The first and sixth authors' research was supported by the NIH/NIDDK Intramural Research Program.
Bernard FendlerCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724. This author's research was supported by the Simons Foundation and the Starr Cancer Consortium (I3-A123).
Matthew J MerrinsUniversity of Michigan, Ann Arbor, MI 48105. The third author's research was supported by the National Institutes of Health (F32-DK085960), and the fourth author's research was supported by the National Institutes of Health (R01-DK46409).
Leslie S SatinUniversity of Michigan, Ann Arbor, MI 48105. The third author's research was supported by the National Institutes of Health (F32-DK085960), and the fourth author's research was supported by the National Institutes of Health (R01-DK46409).
Richard BertramDepartment of Mathematics and Programs in Neuroscience and Molecular Biophysics, Florida State University, Tallahassee, FL 32306. This author's research was supported by the National Institutes of Health (DK080714).
Arthur ShermanNational Institutes of Health, Bethesda, MD 20892. The first and sixth authors' research was supported by the NIH/NIDDK Intramural Research Program.
National Institutes of Health · USU.S. National Science Foundation · USCold Spring Harbor Laboratory · USFlorida State University · US

Funding

METABOLICALLY-COUPLED ION CHANNEL INTERACTIONS IN ISLETSR01DK046409 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SATIN, LESLIE S. · 1994 to 2023
$9.1M
Stimulus secretion coupling in pancreatic beta-cellsZIADK013027 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI SHERMAN, ARTHUR · 2009 to 2025
$3.6M
Stimulus secretion coupling in pancreatic beta-cellsZ01DK013027 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI SHERMAN, ARTHUR · 2007 to 2008
$624k
Cyclin-Dependant Kinase 2 (CDK2) Function in Pancreatic Beta-CellsK01DK101683 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MERRINS, MATTHEW J. · 2014 to 2016
$426k
Intramural NIH HHS Z01 DK013027NIDDK NIH HHS K01 DK101683NIDDK NIH HHS R01 DK046409
6 · The paper itself

Abstract

Pancreatic islets exhibit bursting oscillations in response to elevated blood glucose. These oscillations are accompanied by oscillations in the free cytosolic Ca

Indexed as

calciumdual oscillator modelmetabolicoscillationspancreatic β-cells

Identifiers

PMID25698909
PMCPMC4331037
OpenAlexW2089495621

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.