ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Valproate-induced neurodevelopmental deficits in Xenopus laevis tadpoles.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
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- Ocular manifestations in autism spectrum disorder.International journal of ophthalmology · 2025Review
- X-Tracker: Automated Analysis of Xenopus Tadpole Visual Avoidance Behavior.bioRxiv : the preprint server for biology · 2024Article
- Characterization of NaLife science alliance · 2024Article
- Habituation in anuran tadpoles and the role of risk uncertainty.Animal cognition · 2022Article
- Epigenetic regulation of GABAergic differentiation in the developing brain.Frontiers in cellular neuroscience · 2022Article
- Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity ineLife · 2021Article
- Early Developmental Exposure to Fluoxetine and Citalopram Results in Different Neurodevelopmental Outcomes.Neuroscience · 2021Article
- Preclinical Assessment of a New Hybrid Compound C11 Efficacy on Neurogenesis and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice.International journal of molecular sciences · 2021Article
- Abnormal Reinnervation of Denervated Areas Following Nerve Injury Facilitates Neuropathic Pain.Cells · 2020Article
- Xenbase: Facilitating the Use ofFrontiers in physiology · 2019Review
- Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods.Toxicology and applied pharmacology · 2018Article
- Autism Pathogenesis: The Superior Colliculus.Frontiers in neuroscience · 2018Article
- A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy.International journal of molecular sciences · 2017Article
- Article
- Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits.Neural development · 2016Article
- Emergence of Selectivity to Looming Stimuli in a Spiking Network Model of the Optic Tectum.Frontiers in neural circuits · 2016Article
- Pentylenetetrazole-induced seizures in developing rats prenatally exposed to valproic acid.PeerJ · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Autism spectrum disorder (ASD) is increasingly thought to result from low-level deficits in synaptic development and neural circuit formation that cascade into more complex cognitive symptoms. However, the link between synaptic dysfunction and behavior is not well understood. By comparing the effects of abnormal circuit formation and behavioral outcomes across different species, it should be possible to pinpoint the conserved fundamental processes that result in disease. Here we use a novel model for neurodevelopmental disorders in which we expose Xenopus laevis tadpoles to valproic acid (VPA) during a critical time point in brain development at which neurogenesis and neural circuit formation required for sensory processing are occurring. VPA is a commonly prescribed antiepileptic drug with known teratogenic effects. In utero exposure to VPA in humans or rodents results in a higher incidence of ASD or ASD-like behavior later in life. We find that tadpoles exposed to VPA have abnormal sensorimotor and schooling behavior that is accompanied by hyperconnected neural networks in the optic tectum, increased excitatory and inhibitory synaptic drive, elevated levels of spontaneous synaptic activity, and decreased neuronal intrinsic excitability. Consistent with these findings, VPA-treated tadpoles also have increased seizure susceptibility and decreased acoustic startle habituation. These findings indicate that the effects of VPA are remarkably conserved across vertebrate species and that changes in neural circuitry resulting from abnormal developmental pruning can cascade into higher-level behavioral deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.