ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
The PDZ-domain protein Whirlin facilitates mechanosensory signaling in mammalian proprioceptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Induced Proprioceptor and Low-Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Biophysical model of muscle spindle encoding.Experimental physiology · 2024Review
- Mechanosensory encoding in ex vivo muscle-nerve preparations.Experimental physiology · 2024Review
- LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period.The Journal of cell biology · 2023Article
- Molecular determinants of mechanosensation in the muscle spindle.Current opinion in neurobiology · 2022Review
- Vesicle-released glutamate is necessary to maintain muscle spindle afferent excitability but not dynamic sensitivity in adult mice.The Journal of physiology · 2021Article
- Molecular correlates of muscle spindle and Golgi tendon organ afferents.Nature communications · 2021Article
- Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart.Journal of anatomy · 2021Article
- Cancer Exacerbates Chemotherapy-Induced Sensory Neuropathy.Cancer research · 2020Article
- A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Usher syndrome and non-syndromic deafness: Functions of different whirlin isoforms in the cochlea, vestibular organs, and retina.Hearing research · 2019Review
- Role of muscle spindle feedback in regulating muscle activity strength during walking at different speed in mice.Journal of neurophysiology · 2018Article
- Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing.Journal of biomedical science · 2018Review
- Gene Therapy Restores Balance and Auditory Functions in a Mouse Model of Usher Syndrome.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Gene Therapy Restores Hair Cell Stereocilia Morphology in Inner Ears of Deaf Whirler Mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Article
- Whirlin increases TRPV1 channel expression and cellular stability.Biochimica et biophysica acta · 2016Article
- Piezo2 is the principal mechanotransduction channel for proprioception.Nature neuroscience · 2015Article
- Reduced voluntary running performance is associated with impaired coordination as a result of muscle satellite cell depletion in adult mice.Skeletal muscle · 2015Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
Mechanoreception is an essential feature of many sensory modalities. Nevertheless, the mechanisms that govern the conversion of a mechanical force to distinct patterns of action potentials remain poorly understood. Proprioceptive mechanoreceptors reside in skeletal muscle and inform the nervous system of the position of body and limbs in space. We show here that Whirlin/Deafness autosomal recessive 31 (DFNB31), a PDZ-scaffold protein involved in vestibular and auditory hair cell transduction, is also expressed by proprioceptive sensory neurons (pSNs) in dorsal root ganglia in mice. Whirlin localizes to the peripheral sensory endings of pSNs and facilitates pSN afferent firing in response to muscle stretch. The requirement of Whirlin in both proprioceptors and hair cells suggests that accessory mechanosensory signaling molecules define common features of mechanoreceptive processing across sensory systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.