ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Behavior-linked FoxP2 regulation enables zebra finch vocal learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Genetic and molecular mechanisms of the FOXP2-CNTNAP2 pathway in Autism spectrum disorders and speech disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2026Pooled it
- In Depth Characterization of the Promoter Proximal Proteome of Single Copy Locus FOXP2.Molecular & cellular proteomics : MCP · 2026Article
- Change of Spiny Neuron Structure in the Basal Ganglia Song Circuit and Its Regulation by miR-9 during Song Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- LinkedbioRxiv : the preprint server for biology · 2025Article
- Normative aging results in degradation of gene networks in a zebra finch basal ganglia nucleus dedicated to vocal behavior.Neurobiology of aging · 2025Article
- CHIRP-Seq: FOXP2 transcriptional targets in zebra finch brain include numerous speech and language-related genes.BMC neuroscience · 2025Article
- Adeno-associated viral tools to trace neural development and connectivity across amphibians.Developmental cell · 2025Article
- Expression and regulation of SETBP1 in the song system of male zebra finches (Taeniopygia guttata) during singing.Scientific reports · 2024Article
- Genomic loss of GPR108 disrupts AAV transduction in birds.bioRxiv : the preprint server for biology · 2024Article
- Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons.Brain : a journal of neurology · 2023Article
- Precision Medicine as a New Frontier in Speech-Language Pathology: How Applying Insights From Behavior Genomics Can Improve Outcomes in Communication Disorders.American journal of speech-language pathology · 2023Article
- Generative models of birdsong learning link circadian fluctuations in song variability to changes in performance.PLoS computational biology · 2023Article
- Effects of Cortical FoxP1 Knockdowns on Learned Song Preference in Female Zebra Finches.eNeuro · 2023Article
- The pale spear-nosed bat: A neuromolecular and transgenic model for vocal learning.Annals of the New York Academy of Sciences · 2022Article
- Generation and characterization of genome-modified chondrocyte-like cells from the zebra finch cell line immortalized by c-MYC expression.Frontiers in zoology · 2022Article
- Striatal Injury Induces Overall Brain Alteration at the Pallial, Thalamic, and Cerebellar Levels.Biology · 2022Article
- Inhibition of miR-128 Enhances Vocal Sequence Organization in Juvenile Songbirds.Frontiers in behavioral neuroscience · 2022Article
- Avian models for brain mechanisms underlying altered social behavior in autism.Frontiers in physiology · 2022Review
- Molecular networks of the FOXP2 transcription factor in the brain.EMBO reports · 2021Review
- Efficient gene transfer into zebra finch germline-competent stem cells using an adenoviral vector system.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mutations in the FOXP2 transcription factor cause an inherited speech and language disorder, but how FoxP2 contributes to learning of these vocal communication signals remains unclear. FoxP2 is enriched in corticostriatal circuits of both human and songbird brains. Experimental knockdown of this enrichment in song control neurons of the zebra finch basal ganglia impairs tutor song imitation, indicating that adequate FoxP2 levels are necessary for normal vocal learning. In unmanipulated birds, vocal practice acutely downregulates FoxP2, leading to increased vocal variability and dynamic regulation of FoxP2 target genes. To determine whether this behavioral regulation is important for song learning, here, we used viral-driven overexpression of FoxP2 to counteract its downregulation. This manipulation disrupted the acute effects of song practice on vocal variability and caused inaccurate song imitation. Together, these findings indicate that dynamic behavior-linked regulation of FoxP2, rather than absolute levels, is critical for vocal learning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.