ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2015
Automatic registration of misaligned CT attenuation correction maps in Rb-82 PET/CT improves detection of angiographically significant coronary artery disease.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Hybrid cardiovascular imaging. A clinical consensus statement of the european association of nuclear medicine (EANM) and the european association of cardiovascular imaging (EACVI) of the ESC.European journal of nuclear medicine and molecular imaging · 2025Review
- Improvement of motion artifacts using dynamic whole-bodyJapanese journal of radiology · 2024Article
- Casting aside the creep: harnessing cardiorespiratory dynamics to optimize myocardial flow assessment in cardiac PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Moving forward with motion reduction, detection and correction in cardiac PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Effect of PET-CT misalignment on the quantitative accuracy of cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Artificial Intelligence to Improve Risk Prediction with Nuclear Cardiac Studies.Current cardiology reports · 2022Review
- Respiration-averaged CT versus standard CT attenuation map for correction ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Practical Guide for Interpreting and Reporting Cardiac PET Measurements of Myocardial Blood Flow: An Information Statement from the American Society of Nuclear Cardiology, and the Society of Nuclear Medicine and Molecular Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021Article
- Myocardial blood flow: Is motion correction necessary?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Short-term repeatability of myocardial blood flow usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Practical guide for interpreting and reporting cardiac PET measurements of myocardial blood flow: an Information Statement from the American Society of Nuclear Cardiology, and the Society of Nuclear Medicine and Molecular Imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Review
- 3D PET/CTEuropean journal of nuclear medicine and molecular imaging · 2020Article
- The continual innovation of commercial PET/CT solutions in nuclear cardiology: Siemens Healthineers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Updates on Stress Imaging Testing and Myocardial Viability With Advanced Imaging Modalities.Current treatment options in cardiovascular medicine · 2017Review
- Enhancing Cardiac PET by Motion Correction Techniques.Current cardiology reports · 2017Review
- Novel SPECT Technologies and Approaches in Cardiac Imaging.Cardiovascular innovations and applications · 2016Article
- Simultaneous reconstruction of attenuation and activity in cardiac PET can remove CT misalignment artifacts.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Positron emission tomography imaging of coronary atherosclerosis.Future cardiology · 2016Review
- Quantitative outcome of registration methods for correcting cardiac drift in cardiac PET/CT imaging.Journal of applied clinical medical physics · 2016Article
- Automatic registration of misaligned CT attenuation correction maps in Rb-82 PET/CT improves detection of angiographically significant coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to evaluate the utility of fully automated software registration intended to improve CT attenuation correction (CTAC) map misalignments during cardiac (82)Rb PET/CT myocardial perfusion imaging (MPI).
methods171 consecutive patients (108 males, mean age 69 years), undergoing both rest-stress (82)Rb PET/CT MPI and invasive coronary angiography within 6 months (mean 14 days, range 0-170), were studied. List mode data were automatically processed in batch mode to generate transaxial attenuation corrected slices with four different CTAC alignment correction strategies: (i) no alignment correction (NONE); (ii) manual correction (MANUAL); (iii) automated 6-parameter rigid correction (AUTO); and (iv) targeted use of automated correction only where PET-CTAC alignment was initially judged as incorrect on either stress or rest scan (AUTO for misalignment only). Initial and final registration quality was graded (1-3) by an experienced radiologist (1: satisfactory alignment (<2 mm misalignment), 2: slight misalignment (2-5 mm in any direction), or 3: poor (>5 mm misalignment in any direction). Total perfusion deficit (TPD) and ischemic TPD (ITPD) were computed automatically, and their diagnostic accuracy to detect significant coronary artery disease with each realignment technique was assessed using receiver operating characteristic analysis.
resultsThe diagnostic accuracy of ITPD, expressed as area under curve, was .81 ± .03 with no alignment correction (NONE), .83 ± .03 with MANUAL correction, .85 ± .03 with AUTO correction (P < .05 vs. NONE and MANUAL), and .87 ± .03 with the targeted use of AUTO correction (P < .05 vs. NONE, MANUAL and AUTO). Both manual and software corrections increased the percentage of cases with satisfactory PET-CTAC map alignment (P < .05 for all) at rest (from 55% for NONE to 80% for MANUAL and 92% for AUTO) and at stress (from 51% for NONE to 78% for MANUAL and 84% for AUTO).
conclusionThe diagnostic accuracy of (82)Rb PET/CT MPI with automated rigid alignment is improved compared to data with no CTAC scan alignment or with manual alignment. The optimal strategy for diagnostic performance is to apply automatic alignment only in cases which are visually identified as misaligned.
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