Evidence map›Paper›PMID 25698435›Full record

SynthesisThe American journal of psychiatry2015

Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis.

Claudia Cooper, Andrew Sommerlad, Constantine G Lyketsos, Gill Livingston

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The American journal of psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 237 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
237citing papers in PubMed, 13 pooled it
30.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05262257 early_phase1unknown statusstarted 2022, after this paper: background citation

Evaluation and Intervention of Cognitive Function in Patients With Diabetes Mellitus.

Ran2022Enrolled120Registered outcomes4Posted comparisons0ConditionsType2 DiabetesArmsdapagliflozin, Lifestyle Intervention, Metformin
PMID 29368156PMID 29626315PMID 30866531PMID 31430566PMID 32848437PMID 32941881PMID 33187206PMID 34234493PMID 34291435PMID 27570337PMID 26969101PMID 25344694other papers from this trial
Open the trial in the graph
NCT07420426 narecruitingnot on this mapstarted 2025, after this paper: background citation

Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment: a Mixed Methods Study

TypeinterventionalSponsorThe University of Hong KongRan2025 to 2026Enrolled160ConditionsMild Cognitive Impairment (MCI)Armsautomated instant message-guided neuropsychiatric symptoms management, general mental health management
3 · Its place in the literature

Who cites it

237 citing papers in PubMed, 13 syntheses or guidelines pooled it, 577 citations in OpenAlex.

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  11. Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2019
    Guideline
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  15. Effect of Initiation and Continuous Adherence to ARBs Versus ACEIs on Risk of Adjudicated Mild Cognitive Impairment or Dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
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  18. Computerized Cognitive Training for Older Adults at Higher Dementia Risk due to Diabetes: Findings From a Randomized Controlled Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020 · on this map
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177 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Claudia CooperFrom the Division of Psychiatry, University College London; and the Department of Psychiatry and Behavioral Sciences, Johns Hopkins Bayview Medical Center, Baltimore.
Andrew Sommerlad
Constantine G Lyketsos
Gill Livingston
Johns Hopkins University · US

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6M
NIA NIH HHS P50 AG-005146NIA NIH HHS P50 AG005146
6 · The paper itself

Abstract

objectivePublic health campaigns encouraging early help seeking have increased rates of mild cognitive impairment (MCI) diagnosis in Western countries, but we know little about how to treat or predict dementia outcomes in persons with the condition.

methodThe authors searched electronic databases and references for longitudinal studies reporting potentially modifiable risk factors for incident dementia after MCI. Two authors independently evaluated study quality using a checklist. Meta-analyses were conducted of three or more studies.

resultsThere were 76 eligible articles. Diabetes and prediabetes increased risk of conversion from amnestic MCI to Alzheimer's dementia; risk in treated versus untreated diabetes was lower in one study. Diabetes was also associated with increased risk of conversion from any-type or nonamnestic MCI to all-cause dementia. Metabolic syndrome and prediabetes predicted all-cause dementia in people with amnestic and any-type MCI, respectively. Mediterranean diet decreased the risk of conversion to Alzheimer's dementia. The presence of neuropsychiatric symptoms or lower serum folate levels predicted conversion from any-type MCI to all-cause dementia, but less formal education did not. Depressive symptoms predicted conversion from any-type MCI to all-cause dementia in epidemiological but not clinical studies.

conclusionsDiabetes increased the risk of conversion to dementia. Other prognostic factors that are potentially manageable are prediabetes and the metabolic syndrome, neuropsychiatric symptoms, and low dietary folate. Dietary interventions and interventions to reduce neuropsychiatric symptoms, including depression, that increase risk of conversion to dementia may decrease new incidence of dementia.

Indexed as

Alzheimer DiseaseCognitive DysfunctionDementiaDepressionDiabetes MellitusDiet, MediterraneanDisease ProgressionEducational StatusFolic AcidHumansLongitudinal StudiesMetabolic SyndromePrediabetic StateProtective FactorsRisk FactorsFolic Acid

Identifiers

PMID25698435
OpenAlexW2172196972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.