ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2015
The clinical features, diagnosis, treatment, and prognosis of neuroinvasive listeriosis: a multinational study.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Global Case Fatality of Bacterial Meningitis During an 80-Year Period: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Clinical Characteristics and Outcomes of InvasiveOpen forum infectious diseases · 2026Article
- Prevalence, species diversity, and antimicrobial resistance profile of Listeria monocytogenes in retail meat and dairy products in Southern Ethiopia.Scientific reports · 2026Article
- A Rare Cause of Acute Dysphagia: Listeria Rhombencephalitis.European journal of case reports in internal medicine · 2026Article
- Clinical characteristics and management of Listeria monocytogenes meningitis in children beyond the neonatal stage: a 10 years retrospective study.BMC infectious diseases · 2025Article
- Clinical characteristics and prognostic indicators in Listeria monocytogenes meningoencephalitis: A retrospective case series and literature review.BMC neurology · 2025Review
- Global burden ofTranslational pediatrics · 2025Article
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- A decision analysis of cancer patients and the consumption of ready-to-eat salad.Risk analysis : an official publication of the Society for Risk Analysis · 2025Article
- Clinical Presentations and Nosocomial Infections of Neurolisteriosis.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Review
- Article
- Clinical and microbiological characteristics and follow-up of invasive Listeria monocytogenes infection among hospitalized patients: real-world experience of 16 years from Hungary.BMC microbiology · 2024Observational
- Listeria brain abscess: a therapeutically challenging rare presentation of listeriosis.BMC infectious diseases · 2024Article
- Computed tomography and magnetic resonance imaging findings in central nervous system listeriosis.Neuroradiology · 2024Article
- Clinical characteristics and prognosis of pediatricMicrobiology spectrum · 2024Article
- Probable airborne transmission ofEmerging microbes & infections · 2023Article
- Human Listeriosis.Clinical microbiology reviews · 2023Review
- Analysis of Clinical and Microbiological Features ofInfection and drug resistance · 2023Article
- Evaluation of the epidemiologic, clinical, radiologic, and treatment methods of patients with subacute and chronic meningitis.BMC neurology · 2022Article
- Possible role of low dose dexamethasone administration in listeria monocytogenes meningoencephalitis: A case series.Biomedical reports · 2022Article
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Authors and funding
25 authors at 19 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine the independent risk factors, morbidity, and mortality of central nervous system (CNS) infections caused by Listeria monocytogenes. We retrospectively evaluated 100 episodes of neuroinvasive listeriosis in a multinational study in 21 tertiary care hospitals of Turkey, France, and Italy from 1990 to 2014. The mean age of the patients was 57 years (range, 19-92 years), and 64% were males. The all-cause immunosuppression rate was 54 % (54/100). Forty-nine (49 %) patients were referred to a hospital because of the classical triad of symptoms (fever, nuchal rigidity, and altered level of consciousness). Rhombencephalitis was detected radiologically in 9 (9 %) cases. Twenty-seven (64 %) of the patients who had cranial magnetic resonance imaging (MRI) performed had findings of meningeal and parenchymal involvement. The mean delay in the initiation of specific treatment was 6.8 ± 7 days. Empiric treatment was appropriate in 52 (52 %) patients. The mortality rate was 25 %, while neurologic sequelae occurred in 13 % of the patients. In the multivariate analysis, delay in treatment [odds ratio (OR), 1.07 [95 % confidence interval (CI), 1.01-1.16]] and seizures (OR, 3.41 [95 % CI, 1.05-11.09]) were significantly associated with mortality. Independent risk factors for neurologic sequelae were delay in treatment (OR, 1.07 [95 % CI, 1.006-1.367]) and presence of bacteremia (OR, 45.2 [95 % CI, 2.73-748.1]). Delay in the initiation of treatment of neuroinvasive listeriosis was a poor risk factor for unfavorable outcomes. Bacteremia was one of the independent risk factors for morbidity, while the presence of seizures predicted worse prognosis. Moreover, the addition of aminoglycosides to ampicillin monotherapy did not improve patients' prognosis.
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