Evidence map›Paper›PMID 25697841›Full record

ArticleJournal of Alzheimer's disease : JAD2015

Myelin basic protein associates with AβPP, Aβ1-42, and amyloid plaques in cortex of Alzheimer's disease brain.

Xinhua Zhan, Glen C Jickling, Bradley P Ander, Boryana Stamova, DaZhi Liu, Patricia F Kao, Mariko A Zelin, Lee-Way Jin, Charles DeCarli, Frank R Sharp

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 112 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. In vivo mapping of cortical amyloid beta-myelin coupling in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Emerging Role of Oligodendrocytes Malfunction in the Progression of Alzheimer's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. CD8Brain, behavior, and immunity · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xinhua ZhanDepartment of Neurology, MIND Institute, University of California at Davis, Sacramento, CA, USA.
Glen C JicklingDepartment of Neurology, MIND Institute, University of California at Davis, Sacramento, CA, USA.
Bradley P AnderDepartment of Neurology, MIND Institute, University of California at Davis, Sacramento, CA, USA.
Boryana StamovaDepartment of Neurology, MIND Institute, University of California at Davis, Sacramento, CA, USA.
DaZhi LiuDepartment of Neurology, MIND Institute, University of California at Davis, Sacramento, CA, USA.
Patricia F KaoAlzheimer's Disease Center, University of California at Davis, Sacramento, CA, USA Department of Pathology, University of California at Davis, Sacramento, CA, USA.
Mariko A ZelinAlzheimer's Disease Center, University of California at Davis, Sacramento, CA, USA Department of Pathology, University of California at Davis, Sacramento, CA, USA.
Lee-Way JinAlzheimer's Disease Center, University of California at Davis, Sacramento, CA, USA Department of Pathology, University of California at Davis, Sacramento, CA, USA.
Charles DeCarliDepartment of Neurology, MIND Institute, University of California at Davis, Sacramento, CA, USA Alzheimer's Disease Center, University of California at Davis, Sacramento, CA, USA.
Frank R SharpDepartment of Neurology, MIND Institute, University of California at Davis, Sacramento, CA, USA.
University of California, Davis · USUniversity of California Davis Medical Center · US

Funding

UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
Heterogeneity of Mild Cognitive Impairment(MCI)R01AG021028 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 2003 to 2014
$4.6M
NRF2 Anti-Oxidant Systems and White Matter HyperintensitiesR01AG042292 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, SHARP, FRANK R · 2013 to 2017
$3.0M
NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG10129NIA NIH HHS R01 AG021028NIA NIH HHS R01 AG042292
6 · The paper itself

Abstract

The goal of this study was to show that myelin and axons in cortical gray matter are damaged in Alzheimer's disease (AD) brain. Superior temporal gyrus gray matter of AD patients (9 male, 14 female) was compared to cognitively normal controls (8 male, 7 female). Myelin basic protein (MBP) and a degraded myelin basic protein complex (dMBP) were quantified by Western blot. Brain sections were immunostained for MBP, dMBP, axonal neurofilament protein (NF), autophagy marker microtubule-associated proteins 1A/B light chain 3B precursor (LC3B), amyloid-β protein precursor (AβPP), and amyloid markers amyloid β1-42 (Aβ1-42) and FSB. Co-immunoprecipitation and mass spectroscopy evaluated interaction of AβPP/Aβ1-42 with MBP/dMBP. Evidence of axonal injury in AD cortex included appearance of AβPP in NF stained axons, and NF at margins of amyloid plaques. Evidence of myelin injury in AD cortex included (1) increased dMBP in AD gray matter compared to control (p < 0.001); (2) dMBP in AD neurons; and (3) increased LC3B that co-localized with MBP. Evidence of interaction of AβPP/Aβ1-42 with myelin or axonal components included (1) greater binding of dMBP with AβPP in AD brain; (2) MBP at the margins of amyloid plaques; (3) dMBP co-localized with Aβ1-42 in the core of amyloid plaques in AD brains; and (4) interactions between Aβ1-42 and MBP/dMBP by co-immunoprecipitation and mass spectrometry. We conclude that damaged axons may be a source of AβPP. dMBP, MBP, and NF associate with amyloid plaques and dMBP associates with AβPP and Aβ1-42. These molecules could be involved in formation of amyloid plaques.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCerebral CortexFemaleHumansImmunoprecipitationMaleMyelin Basic ProteinNeurofilament ProteinsPeptide FragmentsPlaque, AmyloidTandem Mass SpectrometryAmyloid beta-Peptidesamyloid beta-protein (1-42)Amyloid beta-Protein PrecursorMyelin Basic Proteinneurofilament protein MNeurofilament ProteinsPeptide FragmentsAlzheimer's diseaseamyloid-βamyloid-β protein precursorautophagyaxon damagedegraded myelin basic proteinmyelin basic protein

Identifiers

PMID25697841
PMCPMC4422390
OpenAlexW1544991924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.