ArticleJournal of Alzheimer's disease : JAD2015
Mortality in mild cognitive impairment varies by subtype, sex, and lifestyle factors: the Mayo Clinic Study of Aging.
Article in Journal of Alzheimer's disease : JAD, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Resting-state abnormalities in amnestic mild cognitive impairment: a meta-analysis.Translational psychiatry · 2016Pooled it
- Subjective memory and 5-year all-cause mortality in subjective cognitive decline, non-amnestic mild cognitive impairment, and amnestic mild cognitive impairment.GeroScience · 2026Article
- 6-Month Recovery after Mild Traumatic Brain Injury in Older Adults: A TRACK-GERI Study.medRxiv : the preprint server for health sciences · 2026Article
- Combined effect of cognitive dysfunction and sleep disturbance on mortality risk: NHANES 2011-2014.Annals of general psychiatry · 2025Article
- Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity.JAMA · 2025Observational
- Development of Modified Japanese Versions of Questionnaires to Assess Physical and Cognitively Stimulating Activities.JMA journal · 2025Article
- Sex/gender differences in the clinical trajectory of Alzheimer's disease: Insights into diagnosis and cognitive reserve.Frontiers in neuroendocrinology · 2025Review
- Role of cognitive impairment in predicting the long-term risk of all-cause mortality: a 20-year prospective cohort study in China.Archives of public health = Archives belges de sante publique · 2025Article
- A supervised learning method for classifying methylation disorders.BMC bioinformatics · 2024Article
- Impact of mental health on burden of illness, septicemia and mortality among patients hospitalized for cancer.PLOS mental health · 2024Article
- Multimorbidity patterns in dementia and mild cognitive impairment.Frontiers in psychiatry · 2024Article
- Disease severity and mortality in Alzheimer's disease: an analysis using the U.S. National Alzheimer's Coordinating Center Uniform Data Set.BMC neurology · 2023Observational
- Crime, mortality and neurocognitive disorders: A nationwide register study in Finland.International journal of methods in psychiatric research · 2023Article
- Mortality Risks and Causes of Death by Dementia Types in a Japanese Cohort with Dementia: NCGG-STORIES.Journal of Alzheimer's disease : JAD · 2023Article
- Article
- Mortality rate of high cardiovascular risk patients with mild cognitive impairment.Scientific reports · 2022Article
- Review
- Cognitive impairment assessed by Mini-Mental State Examination predicts all-cause and CVD mortality in Chinese older adults: A 10-year follow-up study.Frontiers in public health · 2022Article
- Cognitive impairment and all-cause mortality among Chinese adults aged 80 years or older.Brain and behavior · 2021Article
- Mild cognitive impairment, dementia and risk of mortality in essential tremor: A longitudinal prospective study of elders.Journal of the neurological sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEtiologic differences in mild cognitive impairment (MCI) subtypes may impact mortality.
objectiveTo assess the rate of death in MCI overall, and by subtype, in the population-based Mayo Clinic Study of Aging.
methodsParticipants aged 70-89 years at enrollment were clinically evaluated at baseline and 15-month intervals to assess diagnoses of MCI and dementia. Mortality in MCI cases versus cognitively normal (CN) individuals was estimated using Cox proportional hazards models.
resultsOver a median follow-up of 5.8 years, 331 of 862 (38.4%) MCI cases and 224 of 1,292 (17.3%) cognitively normal participants died. Compared to CN individuals, mortality was elevated in persons with MCI (hazard ratio [HR] = 1.79; 95% CI: 1.41 to 2.27), and was higher for non-amnestic MCI (naMCI; HR = 2.40; 95% CI: 1.72 to 3.36) than for amnestic MCI (aMCI; HR = 1.61; 95% CI: 1.25 to 2.09) after adjusting for confounders. Mortality varied significantly by sex, education, history of heart disease, and engaging in moderate physical exercise (p for interaction <0.05 for all). Mortality rate estimates were highest in MCI cases who were men, did not exercise, had heart disease, and had higher education versus CN without these factors, and for naMCI cases versus aMCI cases without these factors.
conclusionsThese findings suggest stronger impact of etiologic factors on naMCI mortality. Prevention of heart disease, exercise vigilance, may reduce MCI mortality and delayed MCI diagnosis in persons with higher education impacts mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.