ArticleBrain structure & function2016
Topological organization of connectivity strength in the rat connectome.
Article in Brain structure & function, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- NeuroMArVL: An interactive and collaborative web-based tool for visualizing brain networks.Network neuroscience (Cambridge, Mass.) · 2026Article
- Brain connectome from neuronal morphology.Network neuroscience (Cambridge, Mass.) · 2025Article
- Toward a more comprehensive understanding of network centrality disruption in amnestic mild cognitive impairment: a MEG multilayer approach.Alzheimer's research & therapy · 2024Article
- Mapping and comparing fMRI connectivity networks across species.Communications biology · 2023Review
- Trajectory of rich club properties in structural brain networks.Human brain mapping · 2022Article
- Functional Connectivity of the Brain Across Rodents and Humans.Frontiers in neuroscience · 2022Review
- Brain Structure and Function: the first 15 years-a retrospective.Brain structure & function · 2021Article
- Brain network reorganization after targeted attack at a hub region.NeuroImage · 2021Article
- Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network.Neuron · 2021Article
- Dynamical Mechanism Underlying Scale-Free Network Reorganization in Low Acetylcholine States Corresponding to Slow Wave Sleep.Frontiers in network physiology · 2021Article
- Network structure of the mouse brain connectome with voxel resolution.Science advances · 2020Article
- Alterations in the whole brain network organization after prenatal ethanol exposure.The European journal of neuroscience · 2020Article
- Specific and segregated changes to the functional connectome evoked by the processing of emotional faces: A task-based connectome study.Scientific reports · 2020Article
- Mapping the community structure of the rat cerebral cortex with weighted stochastic block modeling.Brain structure & function · 2020Article
- Network topology of the marmoset connectome.Network neuroscience (Cambridge, Mass.) · 2020Article
- Rich-club in the brain's macrostructure: Insights from graph theoretical analysis.Computational and structural biotechnology journal · 2020Review
- The development of brain network hubs.Developmental cognitive neuroscience · 2019Review
- Uncovering the Transcriptional Correlates of Hub Connectivity in Neural Networks.Frontiers in neural circuits · 2019Review
- Connection strength of the macaque connectome augments topological and functional network attributes.Network neuroscience (Cambridge, Mass.) · 2019Article
- Towards Differential Connectomics with NeuroVIISAS.Neuroinformatics · 2019Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The mammalian brain is a complex network of anatomically interconnected regions. Animal studies allow for an invasive measurement of the connections of these networks at the macroscale level by means of neuronal tracing of axonal projections, providing a unique opportunity for the formation of detailed 'connectome maps'. Here we analyzed the macroscale connectome of the rat brain, including detailed information on the macroscale interregional pathways between 67 cortical and subcortical regions as provided by the high-quality, open-access BAMS-II database on rat brain anatomical projections, focusing in particular on the non-uniform distribution of projection strength across pathways. First, network analysis confirmed a small-world, modular and rich club organization of the rat connectome; findings in clear support of previous studies on connectome organization in other mammalian species. More importantly, analyzing network properties of different connection weight classes, we extend previous observations by showing that pathways with different topological roles have significantly different levels of connectivity strength. Among other findings, intramodular connections are shown to display a higher connectivity strength than intermodular connections and hub-to-hub rich club connections are shown to include significantly stronger pathways than connections spanning between peripheral nodes. Furthermore, we show evidence indicating that edges of different weight classes display different topological structures, potentially suggesting varying roles and origins of pathways in the mammalian brain network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.