ReviewExpert review of clinical pharmacology2015
Pharmacological strategies for prevention of postoperative atrial fibrillation.
Review in Expert review of clinical pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Post-Operative Atrial Fibrillation After Surgical Aortic Valve Replacement and the Influence of Statins - Randomized Controlled Trial
Statin Therapy With Atorvastatin in Surgical Aortic Valve Replacement - a Randomized Controlled Trial
Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Effects of rosuvastatin and atorvastatin on nonsustained ventricular tachycardia in patients with ST-elevation myocardial infarction: a retrospective analysis.European journal of clinical pharmacology · 2018Trial
- Artificial intelligence to predict biomarkers for new-onset atrial fibrillation after coronary artery bypass grafting.Turk gogus kalp damar cerrahisi dergisi · 2025Article
- Relevance of Targeting Oxidative Stress, Inflammatory, and Pro-Resolution Mechanisms in the Prevention and Management of Postoperative Atrial Fibrillation.Antioxidants (Basel, Switzerland) · 2025Review
- Postoperative Atrial Fibrillation: A Review.Biomedicines · 2024Review
- Review
- Efficacy and safety of sacubitril/valsartan on postoperative atrial fibrillation in adult patients undergoing cardiac surgery: a real-world observational study.Frontiers in cardiovascular medicine · 2024Article
- Preclinical safety and biodistribution assessment of Ad-KCNH2-G628S administered via atrial painting in New Zealand white rabbits.Basic & clinical pharmacology & toxicology · 2023Article
- Article
- A novel predictive model for new-onset atrial fibrillation in patients after isolated cardiac valve surgery.Frontiers in cardiovascular medicine · 2022Article
- Commentary: We don't need no postop AF… All in all it's just another (β)-block in the wall.JTCVS open · 2020Article
- Simvastatin reduces TGF-β1-induced SMAD2/3-dependent human ventricular fibroblasts differentiation: Role of protein phosphatase activation.International journal of cardiology · 2018Article
- Amiodarone Protocol Provides Cost-Effective Reduction in Postoperative Atrial Fibrillation.The Annals of thoracic surgery · 2018Article
- Aliskiren protecting atrial structural remodeling from rapid atrial pacing in a canine model.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Chamber-specific differences in human cardiac fibroblast proliferation and responsiveness toward simvastatin.American journal of physiology. Cell physiology · 2016Article
- Selective downregulation of mitochondrial electron transport chain activity and increased oxidative stress in human atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2016Article
- Circulating Biomarkers Predictive of Postoperative Atrial Fibrillation.Cardiology in reviewReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Atrial fibrillation (AF) complicating cardiac surgery continues to be a major problem that increases the postoperative risk of stroke, myocardial infarction, heart failure and costs and can affect long-term survival. The incidence of AF after surgery has not significantly changed over the last two decades, despite improvement in medical and surgical techniques. The mechanism and pathophysiology underlying postoperative AF (PoAF) is incompletely understood and results from a combination of acute and chronic factors, superimposed on an underlying abnormal atrial substrate with increased interstitial fibrosis. Several anti-arrhythmic and non-anti-arrhythmic medications have been used for the prevention of PoAF, but the effectiveness of these strategies has been limited due to a poor understanding of the basis for the increased susceptibility of the atria to AF in the postoperative setting. In this review, we summarize the pathophysiology underlying the development of PoAF and evidence behind pharmacological approaches used for its prevention in the postoperative setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.