Evidence map›Paper›PMID 25696820›Full record

ReviewThe Journal of experimental biology2015

Neuronal polarity: an evolutionary perspective.

Melissa M Rolls, Timothy J Jegla

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of experimental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Melissa M RollsDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA mur22@psu.edu.
Timothy J JeglaHuck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.

Funding

Using Drosophila Neurons to Identify Mechanisms that Control Microtubule PolarityR01GM085115 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Melissa Rolls · 2010 to 2026
$5.1M
Characterization of a novel animal model of epilepsy, the Kv12.2 -/- mouseR01NS069842 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI JEGLA, TIMOTHY J · 2010 to 2014
$1.7M
NIGMS NIH HHS R01 GM085115NINDS NIH HHS NS069842NINDS NIH HHS R01 NS069842
6 · The paper itself

Abstract

Polarized distribution of signaling molecules to axons and dendrites facilitates directional information flow in complex vertebrate nervous systems. The topic we address here is when the key aspects of neuronal polarity evolved. All neurons have a central cell body with thin processes that extend from it to cover long distances, and they also all rely on voltage-gated ion channels to propagate signals along their length. The most familiar neurons, those in vertebrates, have additional cellular features that allow them to send directional signals efficiently. In these neurons, dendrites typically receive signals and axons send signals. It has been suggested that many of the distinct features of axons and dendrites, including the axon initial segment, are found only in vertebrates. However, it is now becoming clear that two key cytoskeletal features that underlie polarized sorting, a specialized region at the base of the axon and polarized microtubules, are found in invertebrate neurons as well. It thus seems likely that all bilaterians generate axons and dendrites in the same way. As a next step, it will be extremely interesting to determine whether the nerve nets of cnidarians and ctenophores also contain polarized neurons with true axons and dendrites, or whether polarity evolved in concert with the more centralized nervous systems found in bilaterians.

Indexed as

Biological EvolutionAnimalsAxonsCytoskeletonDendritesInvertebratesMicrotubulesNeuronsAxonAxon initial segmentDendriteMicrotubule

Identifiers

PMID25696820
PMCPMC4334146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.