ArticleProceedings of the National Academy of Sciences of the United States of America2015
Titin ruler hypothesis not refuted.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Mending the Achilles heels of titin in cardiac and musculoskeletal disease.Biophysical reviews · 2026Review
- Titin-dependent biomechanical feedback tailors sarcomeres to specialized muscle functions in insects.Science advances · 2025Article
- The Axial Alignment of Titin on the Muscle Thick Filament Supports Its Role as a Molecular Ruler.Journal of molecular biology · 2020Article
- Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function.Circulation · 2019Article
- The giant protein titin regulates the length of the striated muscle thick filament.Nature communications · 2017Article
- When signalling goes wrong: pathogenic variants in structural and signalling proteins causing cardiomyopathies.Journal of muscle research and cell motility · 2017Review
- Force generation by titin folding.Protein science : a publication of the Protein Society · 2017Article
- Mechanical tension and spontaneous muscle twitching precede the formation of cross-striated muscleDevelopment (Cambridge, England) · 2017Article
- Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice.Journal of molecular and cellular cardiology · 2017Article
- Mechanical Regulation of Cardiac Aging in Model Systems.Circulation research · 2016Review
- Reply to Tskhovrebova et al.: Titin's IA junction does not control thick filament length.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.