ArticleCell cycle (Georgetown, Tex.)2015
Cell divisions are not essential for the direct conversion of fibroblasts into neuronal cells.
Article in Cell cycle (Georgetown, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Proliferation history and transcription factor levels drive direct conversion to motor neurons.Cell systems · 2025Article
- Monocyte Invasion into the Retina Restricts the Regeneration of Neurons from Müller Glia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Proliferation history and transcription factor levels drive direct conversion.bioRxiv : the preprint server for biology · 2023Article
- A natural transdifferentiation event involving mitosis is empowered by integrating signaling inputs with conserved plasticity factors.Cell reports · 2022Article
- Generation of Induced Dopaminergic Neurons from Human Fetal Fibroblasts.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Precision Medicine in Rare Diseases.Diseases (Basel, Switzerland) · 2020Review
- Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons.Nature neuroscience · 2019Article
- Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail.Stem cells international · 2019Article
- Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile.Cell reports · 2018Article
- Alternative dominance of the parental genomes in hybrid cells generated through the fusion of mouse embryonic stem cells with fibroblasts.Scientific reports · 2017Article
- REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.EMBO molecular medicine · 2017Article
- Deterministic versus stochastic model of reprogramming: new evidence from cellular barcoding technique.Open biology · 2017Article
- Inhibition of cell proliferation does not slow down echinoderm neural regeneration.Frontiers in zoology · 2017Article
- The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening.Frontiers in cell and developmental biology · 2017Review
- Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience.Nature reviews. Neuroscience · 2016Review
- Choosing Cell Fate Through a Dynamic Cell Cycle.Current stem cell reports · 2015Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Direct lineage conversion is a promising approach for disease modeling and regenerative medicine. Cell divisions play a key role in reprogramming of somatic cells to pluripotency, however their role in direct lineage conversion is not clear. Here we used transdifferentiation of fibroblasts into neuronal cells by forced expression of defined transcription factors as a model system to study the role of cellular division in the direct conversion process. We have shown that conversion occurs in the presence of the cell cycle inhibitors aphidicolin or mimosine. Moreover, overexpression of the cell cycle activator cMyc negatively influences the process of direct conversion. Overall, our results suggest that cell divisions are not essential for the direct conversion of fibroblasts into neuronal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.