SynthesisPLoS neglected tropical diseases2015
Toxoplasmosis and epilepsy--systematic review and meta analysis.
Synthesis in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Seroprevalence of Toxoplasma gondii infection among patients with psychiatric and neurologic disorders in Türkiye: a systematic review and meta-analysis.BMC psychiatry · 2026Pooled it
- Relationship between Toxoplasma gondii infection and psychiatric disorders in Iran: A systematic review with meta-analysis.PloS one · 2023Pooled it
- Toxoplasma infection and Rhesus blood group system: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Pooled it
- Relationship between toxoplasmosis and obsessive compulsive disorder: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2019Pooled it
- Is there any association between Toxoplasma gondii infection and depression? A systematic review and meta-analysis.PloS one · 2019Pooled it
- Is Toxoplasma Gondii Infection a Risk Factor for Leukemia? An Evidence-Based Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- Investigating the prevalence of Toxoplasma gondii infection in Parkinson's disease patients and its association with disease severity: a case-control study.BMC infectious diseases · 2026Article
- Association between latent toxoplasmosis and bipolar disorder: a case-control seroprevalence study.BMC infectious diseases · 2025Article
- Article
- Toxoplasma gondii IgG serointensity and cognitive function in bipolar disorder.International journal of bipolar disorders · 2024Article
- Effective factors in the pathogenesis ofHeliyon · 2024Review
- Clinical profile of central nervous system space-occupying lesions and their association with CD4 counts in patients with HIV: A prospective observational study.Journal of family medicine and primary care · 2024Article
- Genetic diversity of Toxoplasma gondii in South America: occurrence, immunity, and fate of infection.Parasites & vectors · 2023Review
- Global seroprevalence ofHealth science reports · 2023Article
- Inhibition ofJournal of enzyme inhibition and medicinal chemistry · 2022Article
- Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?Microorganisms · 2022Review
- Toxoplasmosis: Targeting neurotransmitter systems in psychiatric disorders.Metabolic brain disease · 2022Review
- Toxoplasmosis Infection in Newborn: A Systematic Review and Meta-analysis.Advanced biomedical research · 2022Review
- Epigenetic Manipulation of Psychiatric Behavioral Disorders Induced byFrontiers in cellular and infection microbiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundToxoplasmosis is an important, widespread, parasitic infection caused by Toxoplasma gondii. The chronic infection in immunocompetent patients, usually considered as asymptomatic, is now suspected to be a risk factor for various neurological disorders, including epilepsy. We aimed to conduct a systematic review and meta-analysis of the available literature to estimate the risk of epilepsy due to toxoplasmosis.
methodsA systematic literature search was conducted of several databases and journals to identify studies published in English or French, without date restriction, which looked at toxoplasmosis (as exposure) and epilepsy (as disease) and met certain other inclusion criteria. The search was based on keywords and suitable combinations in English and French. Fixed and random effects models were used to determine odds ratios, and statistical significance was set at 5.0%. PRINCIPAL
findingsSix studies were identified, with an estimated total of 2888 subjects, of whom 1280 had epilepsy (477 positive for toxoplasmosis) and 1608 did not (503 positive for toxoplasmosis). The common odds ratio (calculated) by random effects model was 2.25 (95% CI 1.27-3.9), p = 0.005.
conclusionsDespite the limited number of studies, and a lack of high-quality data, toxoplasmosis should continue to be regarded as an epilepsy risk factor. More and better studies are needed to determine the real impact of this parasite on the occurrence of epilepsy.
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