Evidence map›Paper›PMID 25695650›Full record

ArticleJournal of neurophysiology2015

Hyperactivity in the medial olivocochlear efferent system is a common feature of tinnitus and hyperacusis in humans.

Joshua J Sturm, Catherine J C Weisz

Abstract readComment
In one paragraph

Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Auditory Network Discoherence in Chronic Tinnitus.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Clinical and investigational tools for monitoring noise-induced hyperacusis.The Journal of the Acoustical Society of America · 2022
    Review
  6. Article
  7. Effect of Hyperbilirubinemia on Medial Olivocochlear System in Newborns.The journal of international advanced otology · 2019
    Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joshua J SturmDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania jjs149@pitt.edu.
Catherine J C WeiszDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and.
University of Pittsburgh · US

Funding

Synaptic Circuitry of Auditory NeuronsZIADC000091 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI WEISZ, CATHERINE · 2016 to 2025
$17.2M
Intrinsic Connectivity of the Auditory Midbrain in a Mouse Model of TinnitusF30DC014177 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STURM, JOSHUA JOSEPH · 2014 to 2016
$142k
Presynaptic GABA-A receptor activation in auditory brainstem axon terminalsF32DC013207 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WEISZ, CATHERINE JEANNE CHALENSKI · 2013 to 2014
$102k
NIDCD NIH HHS 1F32DC013207NIDCD NIH HHS F30 DC014177PHS HHS 1F30DCO14177
6 · The paper itself

Abstract

Tinnitus and hyperacusis are common, burdensome sources of morbidity with a high rate of co-occurrence. Knudson et al. (J Neurophysiol 112: 3197-3208, 2014) demonstrated that efferent suppression of cochlear activity by the medial olivocochlear system is enhanced in individuals with tinnitus and/or hyperacusis. Their findings stress that atypical activity in the efferent auditory pathway may represent a shared substrate, as well as a potential therapeutic target, in tinnitus and hyperacusis.

Indexed as

HyperacusisTinnitusAuditory PathwaysCochleaEfferent PathwaysHumansefferenthyperacusismedial olivocochleartinnitus

Identifiers

PMID25695650
PMCPMC4630185
OpenAlexW2070620917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.