ArticlePLoS neglected tropical diseases2015
Genetic diversity and population structure of Trypanosoma brucei in Uganda: implications for the epidemiology of sleeping sickness and Nagana.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Transcriptome profiles of Trypanosoma brucei rhodesiense in Malawi reveal focus specific gene expression profiles associated with pathology.PLoS neglected tropical diseases · 2024Article
- Infection withJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Genetic connectivity of trypanosomes between tsetse-infested and tsetse-free areas of Kenya.Parasitology · 2022Article
- Signatures of hybridization in Trypanosoma brucei.PLoS pathogens · 2022Article
- An Update on African Trypanocide Pharmaceutics and Resistance.Frontiers in veterinary science · 2022Review
- Investigation on Prevalence of Canine Trypanosomiasis in the Conservation Areas of Bwindi-Mgahinga and Queen Elizabeth in Western Uganda.Journal of parasitology research · 2022Article
- Article
- A spatial genetics approach to inform vector control of tsetse flies (Ecology and evolution · 2018Article
- Opportunities and challenges for modelling epidemiological and evolutionary dynamics in a multihost, multiparasite system: Zoonotic hybrid schistosomiasis in West Africa.Evolutionary applications · 2018Article
- Let's get fISSical: fast in silico synchronization as a new tool for cell division cycle analysis.Parasitology · 2018Review
- Salivarian Trypanosomosis: A Review of Parasites Involved, Their Global Distribution and Their Interaction With the Innate and Adaptive Mammalian Host Immune System.Frontiers in immunology · 2018Review
- Relationship between Trypanosoma brucei rhodesiense genetic diversity and clinical spectrum among sleeping sickness patients in Uganda.BMC research notes · 2017Article
- Genomic analyses of African Trypanozoon strains to assess evolutionary relationships and identify markers for strain identification.PLoS neglected tropical diseases · 2017Article
- Multiple evolutionary origins of Trypanosoma evansi in Kenya.PLoS neglected tropical diseases · 2017Article
- De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.PloS one · 2016Article
- Wild chimpanzees are infected by Trypanosoma brucei.International journal for parasitology. Parasites and wildlife · 2015Article
- Whole genome capture of vector-borne pathogens from mixed DNA samples: a case study of Borrelia burgdorferi.BMC genomics · 2015Article
- Genetic diversity and population structure of Trypanosoma brucei in Uganda: implications for the epidemiology of sleeping sickness and Nagana.PLoS neglected tropical diseases · 2015Article
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11 authors.
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Abstract
backgroundWhile Human African Trypanosomiasis (HAT) is in decline on the continent of Africa, the disease still remains a major health problem in Uganda. There are recurrent sporadic outbreaks in the traditionally endemic areas in south-east Uganda, and continued spread to new unaffected areas in central Uganda. We evaluated the evolutionary dynamics underpinning the origin of new foci and the impact of host species on parasite genetic diversity in Uganda. We genotyped 269 Trypanosoma brucei isolates collected from different regions in Uganda and southwestern Kenya at 17 microsatellite loci, and checked for the presence of the SRA gene that confers human infectivity to T. b. rhodesiense.
resultsBoth Bayesian clustering methods and Discriminant Analysis of Principal Components partition Trypanosoma brucei isolates obtained from Uganda and southwestern Kenya into three distinct genetic clusters. Clusters 1 and 3 include isolates from central and southern Uganda, while cluster 2 contains mostly isolates from southwestern Kenya. These three clusters are not sorted by subspecies designation (T. b. brucei vs T. b. rhodesiense), host or date of collection. The analyses also show evidence of genetic admixture among the three genetic clusters and long-range dispersal, suggesting recent and possibly on-going gene flow between them.
conclusionsOur results show that the expansion of the disease to the new foci in central Uganda occurred from the northward spread of T. b. rhodesiense (Tbr). They also confirm the emergence of the human infective strains (Tbr) from non-infective T. b. brucei (Tbb) strains of different genetic backgrounds, and the importance of cattle as Tbr reservoir, as confounders that shape the epidemiology of sleeping sickness in the region.
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