SynthesisNPJ primary care respiratory medicine2015
When should acute exacerbations of COPD be treated with systemic corticosteroids and antibiotics in primary care: a systematic review of current COPD guidelines.
Synthesis in NPJ primary care respiratory medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Berbamine Targets TNFAIP3: A Bioactive Compound Alleviates Oxidative Stress and Inflammation in the Comorbidity of Insomnia and Chronic Obstructive Pulmonary Disease Through Multi-Omics Integration.International journal of molecular sciences · 2025Article
- Association Between Dietary Fiber Intake and Prevalence of Chronic Obstructive Pulmonary Disease in a Middle-Aged and Elderly Population: a Study Based on the National Health and Nutrition Examination Survey Database.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Nomograms for Predicting High Hospitalization Costs and Prolonged Stay among Hospitalized Patients with pAECOPD.Canadian respiratory journal · 2024Observational
- Efficacy and safety of oral corticosteroids to treat outpatients with acute exacerbations of COPD in primary care: a multicentre pragmatic randomised controlled study.ERJ open research · 2023Article
- Links Between Inflammatory Bowel Disease and Chronic Obstructive Pulmonary Disease.Frontiers in immunology · 2020Review
- Do Benefits Outweigh Risks for Corticosteroid Therapy in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in People with Diabetes Mellitus?International journal of chronic obstructive pulmonary disease · 2020Review
- The Association of Glucocorticosteroid Treatment with WBC Count in Patients with COPD Exacerbation.Journal of clinical medicine · 2019Article
- Comparative analysis of medical expenditure with nebulized budesonide versus systemic corticosteroids in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease in China.International journal of chronic obstructive pulmonary disease · 2019Observational
- Comparative Effectiveness Of Fluoroquinolone Antibiotic Use In Uncomplicated Acute Exacerbations Of COPD: A Multi-Cohort Study.International journal of chronic obstructive pulmonary disease · 2019Article
- Guideline adherence in hospital recruited and population based COPD patients.BMC pulmonary medicine · 2018Observational
- Exacerbations of COPD.European respiratory review : an official journal of the European Respiratory Society · 2018Review
- Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection.Inflammopharmacology · 2017Article
- Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation.Canadian respiratory journal · 2017Article
- Real-life data on antibiotic prescription and sputum culture diagnostics in acute exacerbations of COPD in primary care.International journal of chronic obstructive pulmonary disease · 2017Article
- How do general practitioners implement decision-making regarding COPD patients with exacerbations? An international focus group study.International journal of chronic obstructive pulmonary disease · 2016Article
- Drop in lung function during asthma and COPD exacerbations - can it be assessed without spirometry?International journal of chronic obstructive pulmonary disease · 2016Observational
- Novel aspects of pathogenesis and regeneration mechanisms in COPD.International journal of chronic obstructive pulmonary disease · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Not all patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) benefit from treatment with systemic corticosteroids and antibiotics. The aim of the study was to identify criteria recommended in current COPD guidelines for treating acute exacerbations with systemic corticosteroids and antibiotics and to assess the underlying evidence. Current COPD guidelines were identified by a systematic literature search. The most recent guidelines as per country/organisation containing recommendations about treating acute exacerbations of COPD were included. Guideline development and criteria for treating acute exacerbations with systemic corticosteroids and antibiotics were appraised. Randomised controlled trials directly referred to in context with the recommendations were evaluated in terms of study design, setting, and study population. A total of 19 COPD guidelines were included. Systemic corticosteroids were often universally recommended to all patients with acute exacerbations. Criteria for treatment with antibiotics were mainly an increase in respiratory symptoms. Objective diagnostic tests or clinical examination were only rarely recommended. Only few criteria were directly linked to underlying evidence, and the trial patients represented a highly specific group of COPD patients. Current COPD guidelines are of little help in primary care to identify patients with acute exacerbations probably benefitting from treatment with systemic corticosteroids and antibiotics in primary care, and might contribute to overuse or inappropriate use of either treatment.
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