ArticleAmerican journal of respiratory and critical care medicine2015
Human trachealis and main bronchi smooth muscle are normoresponsive in asthma.
Article in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- The testosterone paradox in asthma.Frontiers in allergy · 2026Review
- Methacholine hyperresponsiveness in mice with house dust mite-induced lung inflammation is not associated with excessive airway constriction ex vivo.Experimental physiology · 2025Article
- N-cadherin antagonism is bronchoprotective in severe asthma models.Science advances · 2024Article
- Bronchomotor tone imbalance evokes airway hyperresponsiveness.Expert review of respiratory medicine · 2024Review
- High throughput screening of airway constriction in mouse lung slices.Scientific reports · 2024Article
- Critical roles of airway smooth muscle in mediating deep-inspiration-induced bronchodilation: a big stretch?Respiratory research · 2023Review
- Airway smooth muscle function in asthma.Frontiers in physiology · 2022Review
- Structure and function of small airways in asthma patients revisited.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Smooth Muscle Hypocontractility and Airway Normoresponsiveness in a Mouse Model of Pulmonary Allergic Inflammation.Frontiers in physiology · 2021Article
- Airway smooth muscle adapting in dynamic conditions is refractory to the bronchodilator effect of a deep inspiration.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Airway smooth muscle tone increases actin filamentogenesis and contractile capacity.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Asthma: A Loss of Post-natal Homeostatic Control of Airways Smooth Muscle With Regression Toward a Pre-natal State.Frontiers in pediatrics · 2020Review
- Prestrain and cholinergic receptor-dependent differential recruitment of mechanosensitive energy loss and energy release elements in airway smooth muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- The Strain on Airway Smooth Muscle During a Deep Inspiration to Total Lung Capacity.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- Mechanical Abnormalities of the Airway Wall in Adult Mice After Intrauterine Growth Restriction.Frontiers in physiology · 2019Article
- Epithelial Cells Induce a Cyclo-Oxygenase-1-Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype.American journal of respiratory cell and molecular biology · 2017Article
- Regulation of human airway smooth muscle cell migration and relevance to asthma.Respiratory research · 2017Review
- The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics.PloS one · 2017Article
- A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma.Frontiers in pharmacology · 2017Article
- Systems physiology of the airways in health and obstructive pulmonary disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleAirway smooth muscle (ASM) plays a key role in airway hyperresponsiveness (AHR) but it is unclear whether its contractility is intrinsically changed in asthma.
objectivesTo investigate whether key parameters of ASM contractility are altered in subjects with asthma.
methodsHuman trachea and main bronchi were dissected free of epithelium and connective tissues and suspended in a force-length measurement set-up. After equilibration each tissue underwent a series of protocols to assess its methacholine dose-response relationship, shortening velocity, and response to length oscillations equivalent to tidal breathing and deep inspirations. MEASUREMENTS AND MAIN
resultsMain bronchi and tracheal ASM were significantly hyposensitive in subjects with asthma compared with control subjects. Trachea and main bronchi did not show significant differences in reactivity to methacholine and unloaded tissue shortening velocity (Vmax) compared with control subjects. There were no significant differences in responses to deep inspiration, with or without superimposed tidal breathing oscillations. No significant correlations were found between age, body mass index, or sex and sensitivity, reactivity, or Vmax.
conclusionsOur data show that, in contrast to some animal models of AHR, human tracheal and main bronchial smooth muscle contractility is not increased in asthma. Specifically, our results indicate that it is highly unlikely that ASM half-maximum effective concentration (EC50) or Vmax contribute to AHR in asthma, but, because of high variability, we cannot conclude whether or not asthmatic ASM is hyperreactive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.