Evidence map›Paper›PMID 25695521›Full record

ArticlePloS one2015

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice.

Yasmin Husaini, Glen P Lockwood, Trung V Nguyen, Vicky Wang-Wei Tsai, Mohammad G Mohammad, Pamela J Russell, David A Brown, Samuel N Breit

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yasmin HusainiSt. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, NSW 2010, Australia.
Glen P LockwoodSt. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, NSW 2010, Australia.
Trung V NguyenSt. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, NSW 2010, Australia.
Vicky Wang-Wei TsaiSt. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, NSW 2010, Australia.
Mohammad G MohammadSt. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, NSW 2010, Australia.
Pamela J RussellAustralian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, QLD 4102, Australia.
David A BrownSt. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, NSW 2010, Australia.
Samuel N BreitSt. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, NSW 2010, Australia.
St Vincent's Hospital Sydney · AUUNSW Sydney · AUSt Vincent's Hospital · AUTranslational Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The divergent TGF-β superfamily member, macrophage inhibitory cytokine-1 (MIC-1/GDF15), is overexpressed by most cancers, including prostate cancer (PCa). Whilst its circulating levels are linked to cancer outcome, the role MIC-1/GDF15 plays in cancer development and progression is incompletely understood. To investigate its effect on PCa development and spread, we have used TRAMP prostate cancer prone mice bearing a germline deletion of MIC-1/GDF15 (TRAMPMIC-/-). On average TRAMPMIC-/- mice died about 5 weeks earlier and had larger prostatic tumors compared with TRAMP mice that were wild type for MIC-1/GDF15 (TRAMPMIC+/+). Additionally, at the time of death or ethical end point, even when adjusted for lifespan, there were no significant differences in the number of mice with metastases between the TRAMPMIC+/+ and TRAMPMIC-/- groups. However, consistent with our previous data, more than twice as many TRAMP mice overexpressing MIC-1/GDF15 (TRAMPfmsmic-1) had metastases than TRAMPMIC+/+ mice (p<0.0001). We conclude that germ line gene deletion of MIC-1/GDF15 leads to increased local tumor growth resulting in decreased survival consistent with an overall protective role for MIC-1/GDF15 in early primary tumor development. However, in advancing disease, as we have previously noted, MIC-1/GDF15 overexpression may promote local invasion and metastatic spread.

Indexed as

AnimalsGene DeletionGrowth Differentiation Factor 15MaleMiceMice, TransgenicProstatic NeoplasmsGrowth Differentiation Factor 15

Identifiers

PMID25695521
PMCPMC4335046
OpenAlexW2071084003

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.