ArticleCell transplantation2015
Extensive Characterization of Platelet Gel Releasate From Cord Blood in Regenerative Medicine.
Article in Cell transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Synthesis of a temperature responsive semi-inter-penetrating polymer network of poly (diethyl acrylamide)-xanthan gum enriched with umbilical cord blood serum for wound healing.International journal of pharmaceutics: X · 2026Article
- Article
- In vitro regenerative effects of a pooled pathogen-reduced lyophilized human cord blood platelet lysate for wound healing applications.Blood transfusion = Trasfusione del sangue · 2024Article
- Why might cord blood be a better source of platelets for transfusion to neonates?Blood transfusion = Trasfusione del sangue · 2024Review
- Multi-component cord blood banking: a proof-of-concept international exercise.Blood transfusion = Trasfusione del sangue · 2023Article
- Effects of Platelet Lysate Gels Derived from Different Blood Sources on Oral Mucosal Wound Healing: An In Vitro Study.Gels (Basel, Switzerland) · 2023Article
- In Vitro Cell Proliferation and Migration Properties of Oral Mucosal Fibroblasts: A Comparative Study on the Effects of Cord Blood- and Peripheral Blood-Platelet Lysate.International journal of molecular sciences · 2023Article
- Safety and efficacy of eye drops from umbilical cord blood platelet lysate to treat resistant corneal ulcer.Medical hypothesis, discovery & innovation ophthalmology journal · 2022Article
- Cord Blood Platelet Gel as a Treatment of Occipital Pressure Injuries in Newborns: Report of Two Cases.Children (Basel, Switzerland) · 2021Article
- Recycling Apparent Waste Into Biologicals: The Case of Umbilical Cord Blood in Italy and Spain.Frontiers in cell and developmental biology · 2021Article
- Cord blood-derived platelet concentrates as starting material for new therapeutic blood components prepared in a public cord blood bank: from product development to clinical application.Blood transfusion = Trasfusione del sangue · 2020Article
- Chemical-defined medium supporting the expansion of human mesenchymal stem cells.Stem cell research & therapy · 2020Article
- Cord Blood Platelet Rich Plasma Derivatives for Clinical Applications in Non-transfusion Medicine.Frontiers in immunology · 2020Article
- Short Term Results of Fibrin Gel Obtained from Cord Blood Units: A Preliminary in Vitro Study.Bioengineering (Basel, Switzerland) · 2019Article
- Generation of a Functioning and Self-Renewing Diaphragmatic Muscle Construct.Stem cells translational medicine · 2019Article
- Plasma-based fast-gelling biohybrid gels for biomedical applications.Scientific reports · 2019Article
- Cord Blood Platelet Lysate: In Vitro Evaluation to Support the Use in Regenerative Medicine.Mediterranean journal of hematology and infectious diseases · 2019Article
- Evaluation of Peripheral Blood and Cord Blood Platelet Lysates in Isolation and Expansion of Multipotent Mesenchymal Stromal Cells.Bioengineering (Basel, Switzerland) · 2018Article
- Impact of donor characteristics on the quality of bone marrow as a source of mesenchymal stromal cells.American journal of stem cells · 2018Article
- Platelet gel: a new therapeutic tool with great potential.Blood transfusion = Trasfusione del sangue · 2017Review
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelet gel derived from peripheral blood is widely applied in many clinical fields of surgery as biomaterial containing growth factors with high proliferative properties. In 2010, we studied and patented a platelet gel derived from cord blood. In this study, due to the crucial role of the factors released by the platelet gel, we first extended the characterization of its releasate. Using a wide proteomic array and splitting the two components of the releasate, that is, platelets and plasma, we have been able to study their growth factor content. Interestingly, we discovered high levels of hormones and molecules able to support tissue growth in the cord blood platelet gel releasate and, in addition, higher concentrations of several angiogenic factors if compared with the peripheral blood counterpart. On the contrary, the latter was much richer in inflammatory factors. The second aim of our work was to study the effects on cell culture, immunophenotype, and function of mesenchymal stem cells exposed to these two platelet gel releasates as substitute for the animal serum. Since our findings nicely show that the use of the peripheral versus the cord blood platelet gel releasate can differently influence the mesenchymal stem cell commitment, we can suggest that in addition to its peculiar angiogenic properties cord blood platelet gel releasate shows excellent proliferative properties as cell culture supplement.
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