ArticleBioMed research international2015
Electroencephalographic changes associated with antinociceptive actions of lidocaine, ketamine, meloxicam, and morphine administration in minimally anaesthetized dogs.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Opioid-Sparing Analgesia Impacts the Perioperative Anesthetic Management in Major Abdominal Surgery.Medicina (Kaunas, Lithuania) · 2022Trial
- Effect of ketamine combined with lidocaine in pediatric anesthesia.Journal of clinical laboratory analysis · 2020Trial
- Density Spectral Array Patterns During Total Intravenous Anesthesia with Intravenous Lidocaine for Craniotomy: An Illustrative Two-Case Series.International medical case reports journal · 2026Article
- Quantitative Variables Derived from the Electroencephalographic Signal to Assess Depth of Anaesthesia in Animals: A Narrative Review.Animals : an open access journal from MDPI · 2025Review
- Do bulls experience pain or stress during electroejaculation? Evidence from electroencephalography, behavioral, hormonal, and metabolite profiling.Veterinary world · 2025Article
- Importance of Knife Sharpness during Slaughter: Shariah and Kosher Perspective and Scientific Validation.Animals : an open access journal from MDPI · 2023Review
- Electroencephalogram and Physiological Responses as Affected by Slaughter Empathy in Goats.Animals : an open access journal from MDPI · 2023Article
- Application of Electroencephalography in Preslaughter Management: A Review.Animals : an open access journal from MDPI · 2022Review
- The Effects of Stocking Density and Distances on Electroencephalographic Changes and Cortisol as Welfare Indicators in Brahman Crossbred Cattle.Animals : an open access journal from MDPI · 2021Article
- Continuous Infusion of Ketamine and Lidocaine Either with or without Maropitant as an Adjuvant Agent for Analgesia in Female Dogs Undergoing Mastectomy.Veterinary medicine international · 2021Article
- Effect of intravenous lignocaine infusion on bispectral index during spinal anaesthesia for caesarean section: A prospective randomised double-blind study.Indian journal of anaesthesia · 2020Article
- Effects of Slaughter Knife Sharpness on Blood Biochemical and Electroencephalogram Changes in Cattle.Animals : an open access journal from MDPI · 2020Article
- The Effects of Sea and Road Transport on Physiological and Electroencephalographic Responses in Brahman Crossbred Heifers.Animals : an open access journal from MDPI · 2019Article
- Nonlinear dynamics captures brain states at different levels of consciousness in patients anesthetized with propofol.PloS one · 2019Article
- Effects of noxious stimuli on the electroencephalogram of anaesthetised chickens (Gallus gallus domesticus).PloS one · 2018Article
- Optimum Drug Combinations for the Sedation of Growing Boars Prior to Castration.Animals : an open access journal from MDPI · 2017Article
- Article
- Validation of a modified algometer to measure mechanical nociceptive thresholds in awake dogs.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of ketamine and lidocaine on electroencephalographic (EEG) changes were evaluated in minimally anaesthetized dogs, subjected to electric stimulus. Six dogs were subjected to six treatments in a crossover design with a washout period of one week. Dogs were subjected to intravenous boluses of lidocaine 2 mg/kg, ketamine 3 mg/kg, meloxicam 0.2 mg/kg, morphine 0.2 mg/kg and loading doses of lidocaine 2 mg/kg followed by continuous rate infusion (CRI) of 50 and 100 mcg/kg/min, and ketamine 3 mg/kg followed by CRI of 10 and 50 mcg/kg/min. Electroencephalogram was recorded during electrical stimulation prior to any drug treatment (before treatment) and during electrical stimulation following treatment with the drugs (after treatment) under anaesthesia. Anaesthesia was induced with propofol and maintained with halothane at a stable concentration between 0.85 and 0.95%. Pretreatment median frequency was evidently increased (P < 0.05) for all treatment groups. Lidocaine, ketamine, and morphine depressed the median frequency resulting from the posttreatment stimulation. The depression of median frequency suggested evident antinociceptive effects of these treatments in dogs. It is therefore concluded that lidocaine and ketamine can be used in the analgesic protocol for the postoperative pain management in dogs.
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