Evidence map›Paper›PMID 25695027›Full record

ArticleNephro-urology monthly2014

Evaluation of sarcopenia in renal transplant recipients.

Nihal Ozkayar, Bulent Altun, Meltem Halil, Mehmet E Kuyumcu, Gunes Arik, Yusuf Yesil, Tolga Yildirim, Rahmi Yilmaz, Servet Ariogul, Cetin Turgan

Open access · hybridAbstract read
In one paragraph

Article in Nephro-urology monthly, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Prevalence of Musculoskeletal and Metabolic Disorders in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2024
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  14. Changes in Body Composition, Muscle Strength, and Fat Distribution Following Kidney Transplantation.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021
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  16. Muscle mass assessment in renal disease: the role of imaging techniques.Quantitative imaging in medicine and surgery · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nihal OzkayarDepartment of Nephrology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Bulent AltunDepartment of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Meltem HalilDivision of Geriatric Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Mehmet E KuyumcuDivision of Geriatric Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Gunes ArikDepartment of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Yusuf YesilDivision of Geriatric Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Tolga YildirimDepartment of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Rahmi YilmazDepartment of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Servet AriogulDivision of Geriatric Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Cetin TurganDepartment of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Hacettepe University · TRAnkara Numune Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease can lead to sarcopenia; however, no study has described sarcopenia in the patients undergoing renal transplantation.

objectivesThe aim of the present study was to assess the prevalence of sarcopenia in renal transplant recipients (RTR) and to evaluate the demographic and metabolic risk factors associated with sarcopenia in these patients. PATIENTS AND

methodsSarcopenia was diagnosed by measuring handgrip strength in 166 RTR (68 females and 98 males; mean age, 37.9 ± 11.9 years). Basal metabolic rate, fat mass, free-fat mass, total body water, body mass index, and calf circumference were determined, along with blood biochemistry, vitamin D levels, and glomerular filtration rate.

resultsAmong 166 patients, sarcopenia was present in 34 (20.5%). Handgrip, basal metabolic rate, free fat mass, and total body water were significantly lower in patients with sarcopenia in comparison with those without sarcopenia. There were no differences between patients with and without sarcopenia in terms of mean time since transplantation, the presence of diabetes mellitus, hypertension, coronary artery disease, hyperlipidemia, glomerular filtration rate, and body mass index. Univariate analysis revealed significant differences between patients with and without sarcopenia with respect to age (mean of 43.70 ± 13.97 and 36.37 ± 10.82 years, respectively; P = 0.007) and 25-OH vitamin D levels (median (IQR) of 12 (2-39) and 17.70 (3-68) μg/L, respectively; P = 0.024). There was a statistically significant positive correlation between vitamin D levels and handgrip strength (r = 0.334; P < 0.001). Multivariate regression analysis determined that age was an independent predictive variable of sarcopenia in RTR (β = 1.060; 95% CI, 1.017-1.105; and P = 0.006).

conclusionsChronic renal disease contributes to sarcopenia, which may develop at an earlier age in RTR.

Indexed as

Muscle StrengthRenal TransplantationSarcopenia

Identifiers

PMID25695027
PMCPMC4317720
OpenAlexW2117043688

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.