Evidence map›Paper›PMID 25695008›Full record

ArticleMedical journal of the Islamic Republic of Iran2014

Accuracy of pepsinogens for early diagnosis of atrophic gastritis and gastric cancer in Iranian population.

Abbas Zoalfaghari, Najmeh Aletaha, Nader Roushan, Reza Taslimi, Hossein Foroutan, Bita Faridnia

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PubMed Full text at PMC
In one paragraph

Article in Medical journal of the Islamic Republic of Iran, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Etiology and Prevention of Gastric Cancer.Gastrointestinal tumors · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Abbas Zoalfaghari1. Fellowship of Gastroenterology, Imam Khomeini hospital, Department of Internal Medicine, Division of Gastroenterology, Tehran University of Medical Sciences, Imam Khomeini Hospital, Tehran, Iran. abaszoalfaghari1354@yahoo.com.
Najmeh Aletaha2. Assistant Professor, Department of Internal Medicine, Division of gastroenterology, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran. aletaha@ddrc.ac.ir.
Nader Roushan3. Assistant Professor, Department of Internal Medicine, Division of gastroenterology, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran. nroshan@tums.ac.ir.
Reza Taslimi4. Assistant Professor, Department of Internal Medicine, Division of gastroenterology, Tehran University of Medical Sciences, Tehran, Iran. rtaslimi@tums.ac.ir.
Hossein Foroutan5. Professor of Gastroenterology, Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran. froutan@ams.ac.ir .
Bita Faridnia6. Specialist of Internal Medicine, Tehran, Iran. B.faridnia@yahoo.com .
Imam Khomeini Hospital · IRTehran University of Medical Sciences · IRYahoo (Spain) · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, non-invasive methods for screening atrophic gastritis and gastric cancer are lacking. The purpose of this study was to evaluate the value of serological parameters including serum pepsinogen I (PGI), pepsinogen II (PGII) and pepsinogen I: II ratio for the screening atrophic gastritis and gastric cancer.

methodsThe study population consisted of 132 dyspeptic patients who had undergone upper endoscopy with biopsy. Blood samples for ELISA assays of serum PGI, PGII and IgG antibodies against Helicobacter pylori were drawn. Comparison between the two groups was done by Student's t- test, and Mann Whitney test. Cut-off points were calculated using receiver operating curves (ROC).

resultsMean (±SD) age of the study population was 51.4 (±15.5) years. Values of PGI and PG ratio decreased significantly in the atrophic gastritis as compared with the control group (p<0.05). Values of PG and PG ratio didn't show any significant difference between the gastric cancer and control group (p>0.05). For patients with atrophic gastritis, the area under the ROC for PGI was 0.639 (95% CI:0.538-0.741, p=0.008) in which the best cut-off value was 40μg/L (sensitivity 90%, specificity 67%, accuracy 69%, negative predictive value 92%, YI : 0.429). The area under the ROC for PG ratio was 0.711 (95% CI: 0.617-0.806, p=0.0001) and the best cut-off value was 8 (sensitivity 71%, specificity 71%, accuracy 71%, negative predictive value 86%,YI : 0.431).

conclusionIt seems that PGI, PGI: PGII ratio is potential biomarkers for screening atrophic gastritis with high sensitivity, specificity, accuracy and negative predictive value. Serology could be used as a screening method for the detection of precancerous states due to its convenience, relative low cost and safety.

Indexed as

Atrophic gastritisBiomarkersGastric cancerPepsinogens

Identifiers

PMID25695008
PMCPMC4322333
OpenAlexW2397148405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.