Evidence map›Paper›PMID 25694965›Full record

ArticleQuantitative imaging in medicine and surgery2015

Optical cryoimaging of mitochondrial redox state in bronchopulmonary-dysplasia injury models in mice lungs.

Mohammad MasoudiMotlagh, Reyhaneh Sepehr, Nader Sheibani, Christine M Sorenson, Mahsa Ranji

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Optical Metabolic Imaging of Mitochondrial Dysfunction on HADH Mutant Newborn Rat Hearts.IEEE journal of translational engineering in health and medicine · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mohammad MasoudiMotlagh1 Biophotonics laboratory, University of Wisconsin Milwaukee, Department of Electrical Engineering and Computer Science, 3200 N Cramer St., Milwaukee, WI 53211, USA ; Departments of 2 Ophthalmology and Visual Sciences, and 3 Pediatrics, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705, USA.
Reyhaneh Sepehr1 Biophotonics laboratory, University of Wisconsin Milwaukee, Department of Electrical Engineering and Computer Science, 3200 N Cramer St., Milwaukee, WI 53211, USA ; Departments of 2 Ophthalmology and Visual Sciences, and 3 Pediatrics, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705, USA.
Nader Sheibani1 Biophotonics laboratory, University of Wisconsin Milwaukee, Department of Electrical Engineering and Computer Science, 3200 N Cramer St., Milwaukee, WI 53211, USA ; Departments of 2 Ophthalmology and Visual Sciences, and 3 Pediatrics, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705, USA.
Christine M Sorenson1 Biophotonics laboratory, University of Wisconsin Milwaukee, Department of Electrical Engineering and Computer Science, 3200 N Cramer St., Milwaukee, WI 53211, USA ; Departments of 2 Ophthalmology and Visual Sciences, and 3 Pediatrics, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705, USA.
Mahsa Ranji1 Biophotonics laboratory, University of Wisconsin Milwaukee, Department of Electrical Engineering and Computer Science, 3200 N Cramer St., Milwaukee, WI 53211, USA ; Departments of 2 Ophthalmology and Visual Sciences, and 3 Pediatrics, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705, USA.
University of Wisconsin–Madison · US

Funding

UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2005 to 2026
$12.6M
Novel Antiangiogenic Peptides for Treatment of Exudative AMDR24EY022883 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SHEIBANI, NADER · 2013 to 2017
$6.2M
Integrated Multidisciplinary Strategies for Detection of Diabetic RetinopathiesRC4EY021357 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ASSADI, AMIR H, ASSADI-PORTER, FARIBA M · 2010 to 2010
$3.2M
Novel imaging to identify lung mitochondrial injury and predict recoveryR01HL116530 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI JACOBS, ELIZABETH R · 2013 to 2016
$1.1M
Bcl-2 and ocular neovascularizationR21EY023024 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SORENSON, CHRISTINE M · 2013 to 2014
$410k
NEI NIH HHS P30 EY016665NEI NIH HHS R21 EY023024NEI NIH HHS R24 EY022883NEI NIH HHS RC4 EY021357NHLBI NIH HHS R01 HL116530
6 · The paper itself

Abstract

backgroundBronchopulmonary dysplasia (BPD) is a major cause of morbidity and mortality in premature infants exposed to high levels of oxygen. This is mainly attributed to increased oxidative stress and angiogenesis defects impacting lung alveolarization.

methodsHere we use optical imaging to investigate the role of Bcl-2 in modulation of oxidative stress and angiogenesis and pathogenesis of BPD. Cryoimaging of the mitochondrial redox state of mouse lungs was applied to determine the metabolic state of the lungs from Bcl-2 +/+ (control), Bcl-2-deleted in the endothelium (Bcl-2 VE-cad) and Bcl-2-deficient (Bcl-2 -/-; global null) using mitochondrial metabolic coenzymes NADH (Nicotinamide Adenine Dinucleotide), and FADH2 (Flavin Adenine Dinucleotide) as the primary electron carriers in oxidative phosphorylation.

resultsWe observed a 47% and 26% decrease in the NADH redox in Bcl-2 deficient lungs, Bcl-2 -/- and Bcl-2 VE-cad, respectively.

conclusionsThus, Bcl-2 deficiency is associated with a significant increase in oxidative stress contributing to reduced angiogenesis and enhanced pathogenesis of BPD.

Indexed as

Bcl-2lung tissuemitochondrial redoxoptical imaging

Identifiers

PMID25694965
PMCPMC4312288
OpenAlexW96680159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.