ArticleQuantitative imaging in medicine and surgery2015
Longitudinal label-free optical-resolution photoacoustic microscopy of tumor angiogenesis in vivo.
Article in Quantitative imaging in medicine and surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 48 citations in OpenAlex.
- Vascular graph network for ovarian lesion classification using optical-resolution photoacoustic microscopy.Photoacoustics · 2026Article
- Sub-Diffraction Photoacoustic Microscopy Enabled by a Novel Phase-Shifted Excitation Strategy: A Numerical Study.Sensors (Basel, Switzerland) · 2026Article
- Application of photoacoustic imaging in tumor diagnosis and surgical treatment.Frontiers in oncology · 2026Review
- Local laser fluence estimation in optical resolution optoacoustic angiography employing calibrated ultrasound detector.Photoacoustics · 2025Article
- Detecting metastatic potential of cancer through longitudinal vasculature imaging of biomaterial scaffold using non-invasiveTheranostics · 2025Article
- WSA-MP-Net: Weak-signal-attention and multi-scale perception network for microvascular extraction in optical-resolution photoacoustic microcopy.Photoacoustics · 2024Article
- Longitudinal Monitoring of Angiogenesis in a Murine Window Chamber ModelTissue engineering. Part C, Methods · 2024Article
- Scanning darkfield high-resolution microendoscope for label-free microvascular imaging.Biomedical optics express · 2023Article
- Photoacoustic imaging for microcirculation.Microcirculation (New York, N.Y. : 1994) · 2022Review
- In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response.Nature communications · 2022Article
- Visualizing tumor angiogenesis and boundary with polygon-scanning multiscale photoacoustic microscopy.Photoacoustics · 2022Article
- Combined Fluorescence and Optoacoustic Imaging for Monitoring Treatments against CT26 Tumors with Photoactivatable Liposomes.Cancers · 2021Article
- Suppression of motion artifacts in intravascular photoacoustic image sequences.Biomedical optics express · 2021Article
- Photoacoustic imaging of in vivo hemodynamic responses to sodium nitroprusside.Journal of biophotonics · 2021Article
- Long-Term Imaging of Wound Angiogenesis with Large Scale Optoacoustic Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- [Progress of motion artifact correction in photoacoustic microscopy and photoacoustic tomography].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Article
- Full three-dimensional segmentation and quantification of tumor vessels for photoacoustic images.Photoacoustics · 2020Article
- Towards non-contact photoacoustic imaging [review].Photoacoustics · 2020Review
- In vivo detection of tumor boundary using ultrahigh-resolution optical coherence angiography and fluorescence imaging.Journal of biophotonics · 2020Article
- Photoacoustic Imaging in Tissue Engineering and Regenerative Medicine.Tissue engineering. Part B, Reviews · 2020Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOptical-resolution photoacoustic microscopy (OR-PAM) is a high-resolution imaging technology capable of label-free imaging of the morphology and functions of the microvasculature in vivo. Previous studies of angiogenesis by OR-PAM were carried out primarily with transgenic mice and the mouse ear model. While important findings have been generated using this approach, the application of OR-PAM to the more widely used subcutaneous dorsal tumor models remains challenging, largely due to the respiratory and cardiac motion artifacts, as well as the protruding tumor contours. METHODS AND MATERIALS: A noninvasive dorsal skin-fold (N-DSF) model, along with adaptive z-scanning and a corresponding experimental protocol, is developed. Mammary carcinoma cells (4T1) were administered subcutaneously to the backs of female BALB/c mice for tumor inoculation. The mice were anesthetized using a mixture of isofluorane and oxygen.
resultsIn vivo OR-PAM of angiogenesis with subcutaneous dorsal tumor models in mice has been demonstrated. To test the performance of this method, we have monitored the growth of 4T1 mouse mammary carcinoma in BALB/c mice over a period of 9 days. The major features of tumor angiogenesis, including the change of vascular tortuosity, the dilation of vessel diameters, and the increase of blood supply, have been clearly captured with OR-PAM.
conclusionsIn combination with N-DSF model, OR-PAM has demonstrated outstanding capacity to provide label-free monitoring of angiogenesis in tumor. Thus, OR-PAM is of great potential to find broad biomedical applications in the pathophysiological studies of tumor and the treatments for anti-angiogenesis.
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