ArticleInternational journal of spine surgery2014
Five and ten year follow-up on intradiscal ozone injection for disc herniation.
Article in International journal of spine surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Efficacy of ultrasound guided caudal epidural steroid injection with or without ozone in patients with lumbosacral canal stenosis; a randomized clinical controlled trial.BMC musculoskeletal disorders · 2023Trial
- Ozone Therapy as a Redox-Modulating Strategy in Degenerative Musculoskeletal Diseases: A Clinical-Mechanistic Review.Journal of clinical medicine · 2026Review
- Ozone Treatment Attenuates Neuroinflammation and Alters miRNA Expression in a Rat Model of Post-Traumatic Epilepsy.Neurochemical research · 2026Article
- Pain Relief, Disability, and Hospital Costs After Intradiscal Ozone Treatment or Microdiscectomy for Lumbar Disc Herniation: A 24-Month Real-World Prospective Study.Journal of clinical medicine · 2025Article
- How Effective is Ozone Therapy in Treatment of Lumbar Disc Disease: a Systematic Review of Prospective Studies.Maedica · 2024Article
- The Effectiveness of Ozone Infiltration on Patient-Reported Outcomes in Low Back Pain: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2024Review
- Effects of Ozone Disc Nucleolysis in Management of Herniated Lumbar Intervertebral Disc: A Retrospective Single-Center Study of 149 Patients.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Image-Guided Minimally Invasive Treatment Options for Degenerative Lumbar Spine Disease: A Practical Overview of Current Possibilities.Diagnostics (Basel, Switzerland) · 2024Review
- Ozone Disc Nucleolysis for Cervical Intervertebral Disc Herniation: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Radiation Exposure during Fluoroscopy-Guided Ozone Chemonucleolysis for Lumbar Disc Herniation.Journal of clinical medicine · 2022Review
- Intradiscal injection for the management of low back pain.JOR spine · 2022Article
- Safety and Efficacy of CT-Guided Pulsed Radiofrequency Combined with Steroid and Ozone Injection-Treated Cervical 3-8 Herpes Zoster Neuralgia Using a Posterior and Upper Quarter of the Cervical Foramina Puncture Approach.Journal of pain research · 2022Article
- Ozone as Modulator of Resorption and Inflammatory Response in Extruded Nucleus Pulposus Herniation. Revising Concepts.International journal of molecular sciences · 2021Review
- Transforaminal epidural steroid injection combined with radio frequency for the treatment of lumbar disc herniation: a 2-year follow-up.BMC musculoskeletal disorders · 2021Article
- Lumbar Intradiscal Ozone Chemonucleolysis Applied Together with the Epidural Steroid Treatment.Sisli Etfal Hastanesi tip bulteni · 2021Article
- Metanalysis on the effectiveness of low back pain treatment with oxygen-ozone mixture: Comparison between image-guided and non-image-guided injection techniques.European journal of radiology open · 2021Review
- Ozone therapy for musculoskeletal disorders Current concepts.Acta bio-medica : Atenei Parmensis · 2020Article
- Current concepts for lumbar disc herniation.International orthopaedics · 2019Review
- Comparing the results of intradiscal ozone injection to treat different types of intervertebral disc herniation based on MSU classification.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2019Article
- The Effect of Lumbar Spinal Surgery History on Intradiscal OSisli Etfal Hastanesi tip bulteni · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisc herniation is the most common cause for spinal surgery and many clinicians employ epidural steroid injections with limited success. Intradiscal injection of ozone gas has been used as an alternative to epidural steroids and surgical discectomy. Early results are positive but long-term data are limited.
methodsOne hundred and eight patients with confirmed contiguous disc herniation were treated with intradiscal injection of ozone in 2002-2003. One-hundred seven patients were available for telephone follow-up at 5 years. Sixty patients were available for a similar telephone follow-up at ten years. Patients were asked to describe their clinical outcome since the injection. Surgical events were documented. MRI images were reviewed to assess the reduction in disc herniation at six months.
resultsMRI films demonstrated a consistent reduction in the size of the disc herniation. Seventy-nine percent of patients had a reduction in herniation volume and the average reduction was 56%. There were 19 patients that ultimately had surgery and 12 of them occurred in the first six months after injection. One of these 12 was due to surgery at another level. Two surgeries involved an interspinous spacer indicated by stenosis or DDD. All other surgeries were discectomies. Of the patients that avoided surgery 82% were improved at 5 years and 88% were improved at 10 years. Other than subsequent surgeries, no spine-related complications were experienced. CONCLUSIONS/LEVEL OF EVIDENCE: We conclude that ozone is safe and effective in approximately 75% of patients with disc herniation and the benefit is maintained through ten years. This is a retrospective review and randomized trials are needed. CLINICAL RELEVANCE: Intradiscal ozone injection may enable patients to address their pain without multiple epidural injections and surgery. The benefit of ozone is durable and does not preclude future surgical options. The risk reward profile for this treatment is favorable.
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Registered trials
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