ReviewJournal of thoracic disease2015
Carcinogenicity of ambient air pollution: use of biomarkers, lessons learnt and future directions.
Review in Journal of thoracic disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of Particulate Matter Pollution on Global Lung Cancer Burden: A Systematic Analysis for the Global Burden of Disease Study 1990-2021.Thoracic cancer · 2025Article
- The association between long-term PM2.5 exposure and risk for pancreatic cancer: an application of social informatics.American journal of epidemiology · 2025Article
- Clean energy consumption, sleep duration, and the association of cancer: findings from the China health and retirement longitudinal study.Frontiers in oncology · 2024Article
- Traffic-Related Air Pollution and Ground-Level Ozone Associated Global DNA Hypomethylation and Bulky DNA Adduct Formation.International journal of molecular sciences · 2023Article
- Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health.Frontiers in genetics · 2023Review
- Development and evaluation of an advanced National Air Quality Forecasting Capability using the NOAA Global Forecast System version 16.Geoscientific model development · 2022Article
- The association between ambient air pollutants and pancreatic cancer in the Multiethnic Cohort Study.Environmental research · 2021Article
- Prenatal air pollution exposure and neurodevelopment: A review and blueprint for a harmonized approach within ECHO.Environmental research · 2021Review
- Chronic Low-Dose Exposure to Xenoestrogen Ambient Air Pollutants and Breast Cancer Risk: XENAIR Protocol for a Case-Control Study Nested Within the French E3N Cohort.JMIR research protocols · 2020Article
- Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations.CA: a cancer journal for clinicians · 2020Review
- Ambient air pollution and its influence on human health and welfare: an overview.Environmental science and pollution research international · 2020Review
- Chemical Biomarkers of Exposure and Early Damage from Potentially Carcinogenic Airborne Pollutants.Annals of cancer epidemiology · 2019Article
- The cytotoxic, inflammatory and oxidative potential of coconut oil-substituted diesel emissions on bronchial epithelial cells at an air-liquid interface.Environmental science and pollution research international · 2019Article
- Cluster Analysis Evaluating PM2.5, Occupation Risk and Mode of Transportation as Surrogates for Air-pollution and the Impact on Lung Cancer Diagnosis and 1-Year Mortality.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Physicochemical characteristics, mutagenicity and genotoxicity of airborne particles under industrial and rural influences in Northern Lebanon.Environmental science and pollution research international · 2017Article
- Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone.Mutagenesis · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between ambient air pollution (AAP) exposure and lung cancer risk has been investigated in prospective studies and the results are generally consistent, indicating that long-term exposure to air pollution can cause lung cancer. Biomarkers can enhance research on the health effects of air pollution by improving exposure assessment, increasing the understanding of mechanisms, and enabling the investigation of individual susceptibility. In this review, we assess DNA adducts as biomarkers of exposure to AAP and early biological effect, and DNA methylation as biomarker of early biological change and discuss critical issues arising from their incorporation in AAP health impact evaluations, such as confounding, individual susceptibilities, timing, intensity and duration of exposure, and investigated tissue. DNA adducts and DNA methylation are treated as paradigms. However, the lessons, learned from their use in the examination of AAP carcinogenicity, can be applied to investigations of other biomarkers involved in AAP carcinogenicity.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.