Evidence map›Paper›PMID 25694817›Full record

ReviewJournal of thoracic disease2015

Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study.

Zhanghua Chen, Muhammad T Salam, Sandrah P Eckel, Carrie V Breton, Frank D Gilliland

Open access · greenAbstract readReview
In one paragraph

Review in Journal of thoracic disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Impact of Air Pollution on Health: A Rising Concern in Kathmandu, Nepal.JNMA; journal of the Nepal Medical Association · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
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  15. Analysis of gasoline-related pollutant exposures and risks in California between 1996 and 2014.Journal of exposure science & environmental epidemiology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhanghua Chen1 Department of Preventive Medicine, Division of Environmental Health, 2 Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Muhammad T Salam1 Department of Preventive Medicine, Division of Environmental Health, 2 Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Sandrah P Eckel1 Department of Preventive Medicine, Division of Environmental Health, 2 Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Carrie V Breton1 Department of Preventive Medicine, Division of Environmental Health, 2 Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Frank D Gilliland1 Department of Preventive Medicine, Division of Environmental Health, 2 Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
University of Southern California · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
Urban Air Pollution and Children's Respiratory HealthP01ES011627 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GILLILAND, FRANK D. · 2002 to 2011
$30.2M
INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMAR01ES021801 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID, ALLAYEE, HOOMAN · 2012 to 2016
$3.9M
Early detection of adverse respiratory effects from air pollutionR01ES023262 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERHANE, KIROS T, GILLILAND, FRANK D. · 2013 to 2016
$2.0M
Methods for modeling air pollution effects on exhaled biomarkersK22ES022987 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ECKEL, SANDRAH PROCTOR · 2013 to 2015
$478k
NIEHS NIH HHS K22 ES022987NIEHS NIH HHS P01 ES011627NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES021801NIEHS NIH HHS R01 ES023262
6 · The paper itself

Abstract

Outdoor air pollution is one of the leading contributors to adverse respiratory health outcomes in urban areas around the world. Children are highly sensitive to the adverse effects of air pollution due to their rapidly growing lungs, incomplete immune and metabolic functions, patterns of ventilation and high levels of outdoor activity. The Children's Health Study (CHS) is a continuing series of longitudinal studies that first began in 1993 and has focused on demonstrating the chronic impacts of air pollution on respiratory illnesses from early childhood through adolescence. A large body of evidence from the CHS has documented that exposures to both regional ambient air and traffic-related pollutants are associated with increased asthma prevalence, new-onset asthma, risk of bronchitis and wheezing, deficits of lung function growth, and airway inflammation. These associations may be modulated by key genes involved in oxidative-nitrosative stress pathways via gene-environment interactions. Despite successful efforts to reduce pollution over the past 40 years, air pollution at the current levels still brings many challenges to public health. To further ameliorate adverse health effects attributable to air pollution, many more toxic pollutants may require regulation and control of motor vehicle emissions and other combustion sources may need to be strengthened. Individual interventions based on personal susceptibility may be needed to protect children's health while control measures are being implemented.

Indexed as

Air pollutionasthmagenetic susceptibilityrespiratory diseasetraffic pollution

Identifiers

PMID25694817
PMCPMC4311073
OpenAlexW164076289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.