ArticleJournal of environmental and public health2015
Patterns of exposure to multiple metals and associations with neurodevelopment of preschool children from Montevideo, Uruguay.
Article in Journal of environmental and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- An Assessment of the Consumption of Energy and Selected Minerals and Their Content in the Hair of Children Aged 1-4 Years.Biological trace element research · 2016Trial
- Metal Pollution in the Air and Its Effects on Vulnerable Populations: A Narrative Review.International journal of molecular sciences · 2026Review
- Review
- The relationship between lead levels and reading acquisition in Spanish speakers, evidence from Uruguayan schoolers.Neurotoxicology · 2024Article
- Article
- Impairments of Spatial Memory and N-methyl-d-aspartate Receptors and Their Postsynaptic Signaling Molecules in the Hippocampus of Developing Rats Induced by As, Pb, and Mn Mixture Exposure.Brain sciences · 2023Article
- Pyrethroid and Chlorpyrifos Pesticide Exposure, General Intellectual Abilities, and Executive Functions of School Children from Montevideo, Uruguay.International journal of environmental research and public health · 2023Article
- Prenatal lead (Pb) exposure is associated with differential placental DNA methylation and hydroxymethylation in a human population.Epigenetics · 2022Article
- Associations of maternal urinary arsenic concentrations during pregnancy with childhood cognitive abilities: The HOME study.International journal of hygiene and environmental health · 2022Article
- Association between placental toxic metal exposure and NICU Network Neurobehavioral Scales (NNNS) profiles in the Rhode Island Child Health Study (RICHS).Environmental research · 2022Article
- Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Using the Metabolome to Understand the Mechanisms Linking Chronic Arsenic Exposure to Microglia Activation, and Learning and Memory Impairment.Neurotoxicity research · 2021Article
- Lead exposure and indices of height and weight in Uruguayan urban school children, considering co-exposure to cadmium and arsenic, sex, iron status and dairy intake.Environmental research · 2021Article
- Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis.Environmental health and preventive medicine · 2021Article
- Developmental toxicity of cadmium in infants and children: a review.Environmental analysis, health and toxicology · 2021Article
- Associations of metals and neurodevelopment: a review of recent evidence on susceptibility factors.Current epidemiology reports · 2020Article
- Catching flame retardants and pesticides in silicone wristbands: Evidence of exposure to current and legacy pollutants in Uruguayan children.The Science of the total environment · 2020Article
- Chemical mixtures and neurobehavior: a review of epidemiologic findings and future directions.Reviews on environmental health · 2020Review
- Prevention of Deficit in Neuropsychiatric Disorders through Monitoring of Arsenic and Its Derivatives as Well as Through Bioinformatics and Cheminformatics.International journal of molecular sciences · 2019Review
- Uncovering neurodevelopmental windows of susceptibility to manganese exposure using dentine microspatial analyses.Environmental research · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
While it is known that toxic metals contribute individually to child cognitive and behavioral deficits, we still know little about the effects of exposure to multiple metals, particularly when exposures are low. We studied the association between children's blood lead and hair arsenic, cadmium, and manganese and their performance on the Bayley Scales of Infant Development III. Ninety-two preschool children (age 13-42 months) from Montevideo, Uruguay, provided a hair sample and 78 had a blood lead level (BLL) measurement. Using latent class analysis (LCA), we identified four groups of exposure based on metal concentrations: (1) low metals, (2) low-to-moderate metals, (3) high lead and cadmium, and (4) high metals. Using the four-group exposure variable as the main predictor, and fitting raw scores on the cognitive, receptive vocabulary, and expressive vocabulary scales as dependent variables, both complete-case and multiple imputation (MI) analyses were conducted. We found no association between multiple-metal exposures and neurodevelopment in covariate-adjusted models. This study demonstrates the use of LCA together with MI to determine patterns of exposure to multiple toxic metals and relate these to child neurodevelopment. However, because the overall study population was small, other studies with larger sample sizes are needed to investigate these associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.