Evidence map›Paper›PMID 25694605›Full record

ArticleJournal of virology2015

Herpes simplex virus 1 upregulates p35, alters CDK-5 localization, and stimulates CDK-5 kinase activity during acute infection in neurons.

Heba H Mostafa, Jessica M van Loben Sels, David J Davido

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Contributions of DNA Damage to Alzheimer's Disease.International journal of molecular sciences · 2020
    Review
  4. Human DNA Virus Exploitation of the MAPK-ERK Cascade.International journal of molecular sciences · 2019
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Heba H MostafaDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Jessica M van Loben SelsDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
David J DavidoDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA ddavido@ku.edu.
University of Kansas · US

Funding

MBRS IMSD PROGRAM AT THE UNIVERSITY OF KANSASR25GM062232 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI CARTWRIGHT, PAULYN, HANSON, PAUL R. · 2001 to 2018
$6.9M
NIGMS NIH HHS R25 GM062232
6 · The paper itself

Abstract

The cyclin-dependent kinase 5 (CDK-5) activating protein, p35, is important for acute herpes simplex virus 1 (HSV-1) replication in mice. This report shows that HSV-1 increases p35 levels, changes the primary localization of CDK-5 from the nucleus to the cytoplasm, and enhances CDK-5 activity during lytic or acute infection. Infected neurons also stained positive for the DNA damage response (DDR) marker γH2AX. We propose that CDK-5 is activated by the DDR to protect infected neurons from apoptosis.

Indexed as

Host-Pathogen InteractionsVirus ReplicationAnimalsApoptosisCyclin-Dependent Kinase 5DNA DamageHerpesvirus 1, HumanHistonesMice, KnockoutNeuronsPhosphotransferasesCdk5 protein, mouseCdk5r1 protein, mouseCyclin-Dependent Kinase 5gamma-H2AX protein, mouseHistonesPhosphotransferases

Identifiers

PMID25694605
PMCPMC4403470
OpenAlexW2120720351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.