ArticleJournal of clinical microbiology2015
Matrix-assisted laser desorption ionization-time of flight mass spectrometry meropenem hydrolysis assay with NH4HCO3, a reliable tool for direct detection of carbapenemase activity.
Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Evaluation of the rapid lateral flow assay (LFA) for detection of five major carbapenemase enzyme families in genotypically characterised bacterial isolates.The Indian journal of medical research · 2025Article
- Detecting antibiotic resistance: classical, molecular, advanced bioengineering, and AI-enhanced approaches.Frontiers in microbiology · 2025Review
- Laboratory detection of carbapenemases among Gram-negative organisms.Clinical microbiology reviews · 2024Review
- Antimicrobial and Diagnostic Stewardship of the Novel β-Lactam/β-Lactamase Inhibitors for Infections Due to Carbapenem-Resistant Enterobacterales Species andAntibiotics (Basel, Switzerland) · 2024Review
- Direct Detection of KPC Peak from Positive Blood Cultures Using MALDI-TOF MS: Are We There Yet?Antibiotics (Basel, Switzerland) · 2023Article
- Plasmid-mediated colistin resistance among human clinicalFrontiers in microbiology · 2023Article
- Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases.Scientific reports · 2022Article
- MALDI-TOF mass spectrometry for direct KPC detection among Enterobacterales.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- An Overview on Phenotypic and Genotypic Characterisation of Carbapenem-ResistantMedicina (Kaunas, Lithuania) · 2022Review
- NDM-beta-lactamase-1: Where do we stand?The Indian journal of medical research · 2022Review
- Detection and Characterization of Carbapenemases inFrontiers in microbiology · 2022Article
- Detection of carbapenemase-producing Enterobacterales by means of matrix-assisted laser desorption ionization time-of-flight mass spectrometry with ertapenem susceptibility-testing disks as source of carbapenem substrate.Frontiers in microbiology · 2022Article
- Rapid Detection and Differentiation of KPC and MBL Carbapenemases among Enterobacterales Isolates by a Modified Combined-Disk Test.Polish journal of microbiology · 2021Article
- Detection of carbapenemase producing enterobacteria using an ion sensitive field effect transistor sensor.Scientific reports · 2021Article
- Multicenter Performance Evaluation of MALDI-TOF MS for Rapid Detection of Carbapenemase Activity in Enterobacterales: The Future of Networking Data Analysis With Online Software.Frontiers in microbiology · 2021Article
- Rapid Detection and Characterization of Carbapenemases inJournal of clinical microbiology · 2020Article
- Combination of mass spectrometry and DNA sequencing for detection of antibiotic resistance in diagnostic laboratories.Folia microbiologica · 2020Review
- Evaluation of the Immunochromatographic NG-Test Carba 5, RESIST-5 O.O.K.N.V., and IMPFrontiers in microbiology · 2020Article
- Carbapenemase-producingCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2020Review
- Performance of a Novel Fluorogenic Assay for Detection of Carbapenemase-ProducingJournal of clinical microbiology · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A comparison of a matrix-assisted laser desorption ionization-time of flight mass spectrometric (MALDI-TOF MS) meropenem hydrolysis assay with the Carba NP test showed that both methods exhibited low sensitivity (approximately 76%), mainly due to the false-negative results obtained with OXA-48-type producers. The addition of NH4HCO3 to the reaction buffer for the MALDI-TOF MS assay dramatically improved its sensitivity (98%). Automatic interpretation of the MALDI-TOF MS assay, using the MBT STAR-BL software, generally agreed with the results obtained after manual analysis. For the Carba NP test, spectrophotometric analysis found six additional carbapenemase producers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.