Evidence map›Paper›PMID 25694517›Full record

ArticleJournal of clinical microbiology2015

Genomic and epidemiological characteristics provide new insights into the phylogeographical and spatiotemporal spread of porcine epidemic diarrhea virus in Asia.

Min Sun, Jiale Ma, Yanan Wang, Ming Wang, Wenchao Song, Wei Zhang, Chengping Lu, Huochun Yao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Min SunCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China.
Jiale MaCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China.
Yanan WangCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China.
Ming WangCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China.
Wenchao SongCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Wei ZhangCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China.
Chengping LuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China.
Huochun YaoCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China yaohch@njau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine epidemic diarrhea has become pandemic in the Asian pig-breeding industry, causing significant economic loss. In the present study, 11 complete genomes of porcine epidemic diarrhea virus (PEDV) field isolates from China were determined and analyzed. Frequently occurring mutations were observed, which suggested that full understanding of the genomic and epidemiological characteristics is critical in the fight against PEDV epidemics. Comparative analysis of 49 available genomes clustered the PEDV strains into pandemic (PX) and classical (CX) groups and identified four hypervariable regions (V1 to V4). Further study indicated key roles for the spike (S) gene and the V2 region in distinguishing between the PX and CX groups and for studying genetic evolution. Genotyping and phylogeny-based geographical dissection based on 219 S genes revealed the complexity and severity of PEDV epidemics in Asia. Many subgroups have formed, with a wide array of mutations in different countries, leading to the outbreak of PEDV in Asia. Spatiotemporal reconstruction based on the analysis suggested that the pandemic group strains originated from South Korea and then extended into Japan, Thailand, and China. However, the novel pandemic strains in South Korea that appeared after 2013 may have originated from a Chinese variant. Thus, the serious PED epidemics in China and South Korea in recent years were caused by the complex subgroups of PEDV. The data in this study have important implications for understanding the ongoing PEDV outbreaks in Asia and will guide future efforts to effectively prevent and control PEDV.

Indexed as

Genome, ViralGenomicsAnimalsChinaCluster AnalysisCoronavirus InfectionsDiarrheaEpidemicsEvolution, MolecularGenotypeMolecular EpidemiologyMolecular Sequence DataPhylogeographyPorcine epidemic diarrhea virusRNA, ViralSequence Analysis, DNARNA, Viral

Identifiers

PMID25694517
PMCPMC4400760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.