ArticleAmerican journal of physiology. Renal physiology2015
Spinal stimulation of the upper lumbar spinal cord modulates urethral sphincter activity in rats after spinal cord injury.
Article in American journal of physiology. Renal physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06587841 (Noninvasive Spinal Cord Neuromodulation to Improve Lower Urinary Tract Function After Spinal Cord Injury in Ukrainian War Veterans), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Noninvasive Spinal Cord Neuromodulation to Improve Lower Urinary Tract Function After Spinal Cord Injury in Ukrainian War Veterans
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Spinal cord stimulation to manage autonomic dysfunction after spinal cord injury: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Impact of Electrical Spinal Cord Stimulation on Lower Urinary Tract Dysfunction in Mice With Spinal Cord Injury.International neurourology journal · 2026Article
- Spinal cord neuromodulation for autonomic recovery following spinal cord injury: a scoping review.Journal of neuroengineering and rehabilitation · 2026Article
- Article
- UROREC: A cystometry and electromyography recording system for analyzing urinary incontinence parameters in rat models.PloS one · 2026Article
- Human spinal cord activation during filling and emptying of the bladder.Nature communications · 2025Article
- Enkephalinergic Neurons in Barrington's Nucleus Gate Sex-Specific Control of Micturition.Research square · 2025Article
- Epidural Electrical Stimulation for Functional Recovery in Incomplete Spinal Cord Injury.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- Effects of low-intensity extracorporeal shock wave on bladder and urethral dysfunction in spinal cord injured rats.International urology and nephrology · 2024Article
- Mapping the Iceberg of Autonomic Recovery: Mechanistic Underpinnings of Neuromodulation following Spinal Cord Injury.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Functional mapping of the lower urinary tract by epidural electrical stimulation of the spinal cord in decerebrated cat model.Scientific reports · 2024Article
- Nonbinary 2D Distribution Tool Maps Autonomic Nerve Fiber Clustering in Lumbosacral Ventral Roots of Rhesus Macaques.eNeuro · 2024Article
- Mid-lumbar (L3) epidural stimulation effects on bladder and external urethral sphincter in non-injured and chronically transected urethane-anesthetized rats.Scientific reports · 2023Article
- Prolonged inhibition of bladder function is evoked by low-amplitude electrical stimulation of the saphenous nerve in urethane-anesthetized rats.Physiological reports · 2022Article
- Targeting bladder function with network-specific epidural stimulation after chronic spinal cord injury.Scientific reports · 2022Article
- Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder.Bioelectronic medicine · 2022Article
- Spinal interneurons of the lower urinary tract circuits.Autonomic neuroscience : basic & clinical · 2021Review
- Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats.Scientific reports · 2021Article
- Intraspinal stimulation with a silicon-based 3D chronic microelectrode array for bladder voiding in cats.Journal of neural engineering · 2020Article
- Propriospinal Neurons of L3-L4 Segments Involved in Control of the Rat External Urethral Sphincter.Neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
After spinal cord injury (SCI), the neurogenic bladder is observed to develop asynchronous bladder and external urethral sphincter (EUS) contractions in a condition known as detrusor-sphincter dyssnergia (DSD). Activation of the EUS spinal controlling center located at the upper lumbar spinal cord may contribute to reduce EUS dyssynergic contractions and decrease urethral resistance during voiding. However, this mechanism has not been well studied. This study aimed at evaluating the effects of epidural stimulation (EpS) over the spinal EUS controlling center (L3) in combination with a serotonergic receptor agonist on EUS relaxation in naive rats and chronic (6-8 wk) T8 SCI rats. Cystometrogram and EUS electromyography (EMG) were obtained before and after the intravenous administration of 5HT-1A receptor agonist and antagonist. The latency, duration, frequency, amplitude, and area under curve of EpS-evoked EUS EMG responses were analyzed. EpS on L3 evoked an inhibition of EUS tonic contraction and an excitation of EUS intermittent bursting/relaxation correlating with urine expulsion in intact rats. Combined with a 5HT-1A receptor agonist, EpS on L3 evoked a similar effect in chronic T8 SCI rats to reduce urethral contraction (resistance). This study examined the effect of facilitating the EUS spinal controlling center to switch between urine storage and voiding phases by using EpS and a serotonergic receptor agonist. This novel approach of applying EpS on the EUS controlling center modulates EUS contraction and relaxation as well as reduces urethral resistance during voiding in chronic SCI rats with DSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.