ArticleJournal of dental research2015
DMP1-derived peptides promote remineralization of human dentin.
Article in Journal of dental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Biomimetic strategies for the dentin mineralization, using bioactive molecules: a scoping review and bibliometric analysis (2015-2025).Odontology · 2026Review
- Application of Polymers in Advanced Materials for Enamel and Dentine Remineralization.ACS biomaterials science & engineering · 2026Review
- Advanced biomimetic mineralization approaches for enamel and dentin regeneration: a review.Odontology · 2026Review
- Bioengineered α-Hairpin peptide TKH with GKG linker: a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion.International journal of oral science · 2026Article
- Comparative evaluation of the remineralisation potential of biomimetic agents on phosphorylated dentine using SEM-EDX analysis: an in vitro study.Biomaterial investigations in dentistry · 2026Article
- The development of a collagen-nanoscale hydroxyapatite three-dimensional (3D) in vitro culture system for reproducing osteocyte differentiation and tissue mineralization.Biomaterials · 2026Article
- Serum-derived exosomes of young rats protect bone of ovariectomized rats after fatigue loading in vivo.JBMR plus · 2025Article
- Amyloid-induced mineralization: From biological systems to biomimetic materials.Bioactive materials · 2025Review
- The effects and mechanisms underlying collagen-binding peptides MDPs on dentin remineralization: an in vitro study.BMC oral health · 2025Article
- Assessing the impact of different Urushiol primer solvents on dentin remineralization and bond strength.Clinical oral investigations · 2024Article
- Peptide-Based Biomaterials for Bone and Cartilage Regeneration.Biomedicines · 2024Review
- Remineralization of Dentinal Lesions Using Biomimetic Agents: A Systematic Review and Meta-Analysis.Biomimetics (Basel, Switzerland) · 2023Review
- Peptides in Dentistry: A Scoping Review.Bioengineering (Basel, Switzerland) · 2023Article
- Insight into the development of versatile dentin bonding agents to increase the durability of the bonding interface.Frontiers in dental medicine · 2023Review
- Small organic molecules containing amorphous calcium phosphate: synthesis, characterization and transformation.Frontiers in bioengineering and biotechnology · 2023Article
- Amelotin Promotes Mineralization and Adhesion in Collagen-Based Systems.Cellular and molecular bioengineering · 2022Article
- Promoting effect of a calcium-responsive self-assembly β-sheet peptide on collagen intrafibrillar mineralization.Regenerative biomaterials · 2022Article
- Advances in biomineralization-inspired materials for hard tissue repair.International journal of oral science · 2021Review
- Biomineralization of Enamel and Dentin Mediated by Matrix Proteins.Journal of dental research · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Remineralization of dentin during dental caries is of considerable clinical interest. Dentin matrix protein 1 (DMP1) is a non-collagenous calcium-binding protein that plays a critical role in biomineralization. In the present study, we tested if peptides derived from DMP1 can be used for dentin remineralization. Peptide pA (pA, MW = 1.726 kDa) and peptide pB (pB, MW = 2.185), containing common collagen-binding domains and unique calcium-binding domains, were synthesized by solid-phase chemistry. An extreme caries lesion scenario was created by collagenase digestion, and the biomineral-nucleating potential of these peptides was ascertained when coated on collagenase-treated dentin matrix and control, native human dentin matrix under physiological levels of calcium and phosphate. Scanning electron microscopy analysis suggests that peptide pB was an effective nucleator when compared with pA. However, a 1:4 ratio of pA to pB was determined to be ideal for dentin remineralization, based on hydroxyapatite (HA) morphology and calcium/phosphorus ratios. Interestingly, HA was nucleated on collagenase-challenged dentin with as little as 20 min of 1:4 peptide incubation. Electron diffraction confirmed the presence of large HA crystals that produced a diffraction pattern indicative of a rod-like crystal structure. These findings suggest that DMP1-derived peptides may be useful to modulate mineral deposition and subsequent formation of HA when exposed to physiological concentrations of calcium and phosphate.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.